Arizona Cardinals vs San Francisco 49ers
State Farm Stadium, Glendale, Arizona
16.11.2025, 22.05
Arizona Cardinals vs San Francisco 49ers: Prediction for the match on November 16, 2025
On Sunday afternoon, the San Francisco 49ers and Arizona Cardinals will play each other in an NFC West game. Both teams are coming off divisional losses and need a win to bounce back. Jacoby Brissett will be Arizona's starting quarterback, but it's not clear who will be San Francisco's starting quarterback. Will the choice of quarterback for the 49ers have an effect on the game? Here at Telecom Asia, we break down the matchup and share the top betting picks for this exciting clash.
Claim Your Welcome Bonus!Arizona Cardinals Form and Statistics
This season, Trey McBride has caught 603 yards and six touchdowns, which puts him fourth in the NFL. He has 61 catches, which puts him sixth in the league, and has been targeted 88 times. In six games, Jacoby Brissett has thrown for 1,118 yards, eight touchdowns, and one interception. He completes 60.9% of his passes. Brissett has 82 rushing yards and one rushing touchdown, which puts him seventh on the Cardinals. He averages 13.7 yards per game and 4.3 yards per carry. This season, Marvin Harrison Jr. has caught 34 passes for 525 yards and four touchdowns. He has also been targeted 62 times. Bam Knight has 157 rushing yards and two touchdowns. He gets 22.4 yards per game and 3.3 yards per carry. On defense, Josh Sweat has 18 tackles, 10.0 tackles for loss, eight sacks, and two passes defended. Mack Wilson has made 60 tackles, 3.0 tackles for loss, and one interception. Akeem Davis-Gaither has 49 tackles and 2.0 tackles for loss. In nine games, Calais Campbell has made 26 tackles, 8.0 tackles for loss, and five sacks. Arizona is 3-6 after a 44-22 loss to the Seattle Seahawks last week. In that game, Jacoby Brissett threw for 258 yards and two touchdowns, completing 22 of 44 passes with an 83.3 quarterback rating. Emari Demercado was the best receiver, catching three passes for 40 yards. Zonovan Knight rushed for 28 yards on 10 carries, averaging 2.8 yards per carry.
Arizona Cardinals Team News
Cardinals Injury Report: Cardinals Injury Report , Mack Wilson Sr., LB - Questionable , Xavier Weaver, WR - Questionable , Max Melton, CB - Questionable , Will Johnson, CB - Questionable , Simi Fehoko, WR - Out
San Francisco 49ers: Form and Statistics
This season, Christian McCaffrey has run for 626 yards and scored four touchdowns. He is 44th in the NFL with an average of 62.6 yards per game and 3.5 yards per carry. He has 69 catches for 692 yards (sixth in the NFL) and four touchdowns in the passing game. He averages 69.2 receiving yards and 6.9 catches per game. Mac Jones has passed for 2,151 yards, 13 touchdowns, and six interceptions. He completes 69.6% of his passes and gains an average of 268.9 yards per game and 7.4 yards per attempt. Jauan Jennings has 28 catches for 324 yards and three touchdowns. He catches the ball 3.5 times and runs for 40.5 yards each game. Kendrick Bourne has caught 31 passes for 482 yards, which is an average of 53.6 yards per game. But he hasn't scored a touchdown yet this season. On defense, Dee Winters leads the 49ers with 67 tackles and 5.0 tackles for loss. Bryce Huff has 19 tackles, 6.0 tackles for loss, and four sacks. Tatum Bethune has 61 tackles and 2.0 tackles that led to a loss. Upton Stout has 44 tackles, 3.0 tackles for loss, and one sack. San Francisco is 6-4 going into Week 11. They want to bounce back after losing to the Los Angeles Rams 42-26. Mac Jones threw 33 passes and completed 39 of them for 319 yards and three touchdowns, but he also threw one interception. He had a passer rating of 115.7 at the end. Kendrick Bourne caught one pass for 19 yards, and McCaffrey led the rushing game with 12 carries for 30 yards.
San Francisco 49ers: Team News
San Francisco 49ers Injury Report: Alfred Collins, DT - Questionable, Brandon Aiyuk, WR - PUP-R, Rickey Pearsall, WR - Questionable, Brock Purdy, QB - Questionable, Mykel Williams, DE - IR
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Arizona Cardinals vs San Francisco 49ers Betting Tips & Odds
- Arizona is 5-4-0 against the spread this season. The Cardinals have been underdogs by 3 points or more four times and have covered the spread in three of those games. They’ve hit the over five times this year. Arizona has been the underdog six times and won one of those games. Based on the moneyline, they have a 40.8% chance to win.
- San Francisco has a 5-5 record against the spread this season. The 49ers have been favored by 3 points or more twice and covered the spread once. They’ve hit the over in 60% of their games (six out of 10). As moneyline favorites, San Francisco has won 83.3% of the time (5-1). Their implied win probability in this game is 63.6%.
- In the last five matchups between these teams, San Francisco has won three times. They’ve scored 143 points against Arizona while allowing 131.
Arizona Cardinals vs San Francisco 49ers Match Prediction 16th November 2025
The 49ers got a rude awakening on Sunday. The Niners lost to the Los Angeles Rams by 16 points, who scored 42 points in Santa Clara. The Rams took advantage of a San Francisco defense that was tired and hurt. Even more surprising, they shut down Christian McCaffrey, holding him to just 30 yards on 12 carries, a rare feat for one of the NFL's top players. Mac Jones threw for 319 yards and three touchdowns, but most of that was after the game was over, when the stats didn't matter.
Our match prediction is +3.0 Spread Arizona Cardinals with odds at 1.90 on the 1Xbet bookmaker.
Our betting tip is Over 48.5 Total with odds at 1.90 on the Bet365 bookmaker.
Our final match prediction is the Arizona Cardinals to win with odds at 2.40 on the Betway bookmaker.
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