Arizona Cardinals vs Tennessee Titans Prediction: Arizona Cardinals is an easy moneyline pick for round 5

Arizona Cardinals vs Tennessee Titans: Prediction for the match on October 05, 2025

Tennessee Titans travel again to win their first game of the season. 0-4, they attempted to turn things around against the Arizona Cardinals (2-2) in Glendale on October 5. Uncertainty among bookmakers. The Cardinals lead by 7.5 points and total 41.5. Houston's 26-0 win last week crushed Tennessee's offense. It was their first scoreless game since 2019. Rookie quarterback Cam Ward was angry after the game. He called it his hardest game. Arizona has been living dangerously. Last Thursday, September 25, the Cardinals fell to Seattle. This was their second painful loss in five days. Here at Telecomasia, we will preview this game and offer the best betting opportunities.

Arizona Cardinals: Form and Statistics

Kyler Murray has been sharp as the quarterback, throwing for 742 yards and six touchdowns in four games. He completes almost 67% of his passes and throws for an average of 185 yards per game. His legs are still a weapon; he's already run for 148 yards, but he hasn't scored a touchdown on the ground yet. The Cardinals have some strong players on defense. Mack Wilson is at the center of it all with 35 tackles, two stops for loss, and four broken passes. Calais Campbell is still a strong player, with 14 tackles, four tackles for loss, and three sacks. Josh Sweat has the same number of sacks, but he has also made eight tackles. Jalen Thompson has also helped out in the secondary with 33 tackles, cleaning up anything that gets past the front.

Arizona Cardinals: Team News

Trey McBride is in charge of the air. The tight end has 234 yards and a touchdown, catching 24 of 35 passes, which is the ninth most in the league. He catches the ball six times a week and gets almost 59 yards. Rookie Marvin Harrison Jr. is right behind him, catching 16 of 27 targets for 208 yards and two touchdowns. He is getting 52 yards per game and is starting to click with Murray. Michael Wilson is the last member of the group. He caught six passes for 36 yards and a touchdown. He hasn't done much statistically, but he's been steady when needed.

Tennessee Titans: Form and Statistics

The Titans' offense is stuck. After four weeks, they average less than 13 points per game, the lowest in the league. The only plus? Their defense is fine. It has allowed fewer points than Ravens, Cowboys, and Saints. Last week was terrible. Tennessee ran 46 plays and produced 10 first downs as Houston won 26-0. The Texans doubled their 65 plays. It was obvious they were mad. The Titans are targeting Arizona. The Cardinals are tough yet have lost heartbreaking games. They dropped two straight after blowing fourth-quarter leads: 16–15 at San Francisco and 23–20 at home versus Seattle. Arizona's best rushing back is Tony Pollard, with 261 yards and a touchdown. He averages 65.3 yards per game and 3.8 per rush. He has caught six passes for 55 yards but has yet to score. The Titans must find their groove. Arizona craves redemption. Something must change in Glendale.

Tennessee Titans: Team News

Tennessee freshman quarterback Cameron Ward has passed for 614 yards, two touchdowns, and two interceptions. 51.2% of his passes are completed. He has rushed for 42 yards, averaging 10.5 per game. Passing game standout Elic Ayomanor has caught 12 catches for 151 yards and two scores. Calvin Ridley has 24 targets and 10 receptions for 141 yards without a touchdown. Defense has been solid with 14 tackles, five tackles for loss, and two sacks by Jeffery Simmons. Cody Barton has 29 tackles and an interception, Amani Hooker has 23 tackles and a sack, and Cedric Gray has 33.

Arizona Cardinals vs Tennessee Titans Betting Tips & Odds

• Arizona has owned this matchup lately, winning both of the last two meetings with Tennessee. In those games, the Cardinals outscored the Titans 50–20, proving their edge on both sides of the ball.
• This season, Arizona has covered the spread twice and hit the over just once in four tries. As moneyline favorites, they’re perfect — 2-0 — and oddsmakers give them an 81% chance to keep that streak alive.
• Tennessee’s story is different. The Titans have covered the spread only once this season and are 1-1 when catching 7.5 points or more.
• They’ve gone over the total in two games but remain winless as underdogs in four tries. The moneyline suggests just a 23.3% chance they pull off the upset.

Arizona Cardinals vs Tennessee Titans Match Prediction 5th October 2025

The Titans keep going down, but no one knows where the bottom is. On my chart, they are at about -8.75 right now. The Cardinals should have an easy time in this matchup because they are well-rested and ready. I would confidently take them up to a -10 line. The Moneyline is easy: Arizona all the way. But when it comes to the spread, I think Tennessee will win by 8.5 points. It's a risky edge, but it might work out. I like the over at 41 when it comes to the total. Both teams should be able to move the ball enough to keep the score board busy.

Our match prediction is -5.5 Handicap Arizona Cardinals with odds at 1.10 on the 1Xbet bookmaker.

Our betting tip is Over 41.5 Total with odds at 1.90 on the Bet365 bookmaker.

Our final match prediction is Under 25 Total 1 with odds at 180 on the Betway bookmaker.