Philadelphia Eagles vs Los Angeles Rams Prediction: Super Bowl defending champions to come up top in this contest

Philadelphia Eagles vs Los Angeles Rams: Prediction for the match on September 21, 2025

Prediction for the National Football League on the 21st of September 2025. The Los Angeles Rams head east for Week 3. Their destination: Lincoln Financial Field, home of the Philadelphia Eagles. Both squads are unbeaten, setting the stage for one of the season’s first big showdowns. Here at Telecomasia, we will preview this game and offer the best betting opportunities.

Philadelphia Eagles: Form and Statistics

The Philadelphia Eagles are 2-0 and already look like they could be a contender. They beat the Dallas Cowboys 24-20 in a division game, then beat the Kansas City Chiefs 20-17 in a tense Super Bowl rematch that ended with the "tush push." Jalen Hurts came through again when it mattered most, which helped his reputation grow. He has thrown for 253 yards in two games, completing 75.6% of his passes. He has also rushed for 77 yards and three touchdowns.

Philadelphia Eagles: Team News

Saquon Barkley is still a game-changer. He has run for 148 yards, or 74 yards per game, and scored two touchdowns on the ground. He has also caught six passes for 30 yards. DeVonta Smith has caught seven passes for 69 yards in the air, and Jahan Dotson has caught four passes for 63 yards. The Eagles have a strong offensive line, Barkley's speed, Hurts' ability to be a dual-threat, and a defense led by Jalen Carter.

Los Angeles Rams: Form and Statistics

The Rams have won their first two games. They started the year with a tough 14-9 win over the Texans and then put on a show in a 33-19 win over the Titans. Matthew Stafford has been in charge. He has thrown for 543 yards, three touchdowns, and only one interception. His accuracy has been very good, with a 71% completion rate. He moves the ball 271.5 yards per game and 8.8 yards per attempt on average. The Rams have a lot of players who can make plays on defense. Byron Young has already gotten three sacks, three tackles for loss, and 14 total tackles, which puts him fourth in the NFL in sacks. Nathan Landman has the most tackles on the team with 18, and Kamren Curl has 17 tackles and a sack. Kamren Kinchens has also helped out by making 14 tackles. The changes made in the offseason are working. Poona Ford and Nate Landman have made the run defense tougher, and you can see that both sides of the ball are balanced. This Rams team looks sharp, well-organized, and dangerous at the start of the season.

Los Angeles Rams: Team News

Puka Nacua has become the breakout story at receiver. He has 18 catches, which is the most in the league, and 221 yards, which is the fourth most, on only 20 targets. Davante Adams has also been a reliable weapon. In two games, he has caught 10 passes for 157 yards and a touchdown. Kyren Williams has been the driving force behind the run game. He has run for 132 yards and a touchdown, which is an average of 66 yards per game and 3.8 yards per carry.

Philadelphia Eagles vs Los Angeles Rams Betting Tips & Odds

• Philadelphia has dominated this matchup, winning the last five meetings with Los Angeles. Across those games, the Eagles outscored the Rams by 47 points.
• This season, Philadelphia has one win against the spread in two tries. As a favorite of at least 3.5 points, they’re 0-1 ATS.
• Their games haven’t gone over the total yet, but they’ve been moneyline favorites twice — and won both. The current moneyline gives them a 64.9% chance to win.
• Los Angeles tells a different story. The Rams are 2-0 against the spread and have gone over the total once. This will be their first game as underdogs in 2025. Oddsmakers give them a 39.4% chance to pull off the upset.

Philadelphia Eagles vs Los Angeles Rams Match Prediction 21st September 2025

Both the Eagles and the Rams are 2-0. After two weeks, Philadelphia is in first place in the NFC East, ahead of Dallas in the early chase. Los Angeles, on the other hand, is fighting for a spot in the crowded NFC West, where the 49ers and Seahawks are ahead of them. The Rams' offense has gone off, scoring at least 33 points in both games. The Eagles have been tough, winning games and making Lincoln Financial Field a fortress. They are 8-2 at home in their last 10 games. Head-to-head, Philly wins. They've beaten the Rams two years in a row, both times on the road. The fight on Sunday is more than just a Week 3 game. It's a way to measure. The Eagles will rely on Jalen Hurts' ability to run and throw and Saquon Barkley's strength. Matthew Stafford's steady arm and the dangerous pair of Puka Nacua and Davante Adams will be the Rams' response. It feels like a toss-up. But the defending champions might have just enough to win.

Our match prediction is -2.5 Handicap Philadelphia Eagles with odds at 1.62 on the 1Xbet bookmaker.

Our betting tip is Over 45.5 Total with odds at 1.91 on the Bet365 bookmaker.

Our final match prediction is Philadelphia Eagles to win with odds at 1.60 on the Betway bookmaker.