Multiple European champions Ajax return to the Champions League with a Matchday One fixture against last season's Champions League finalists Inter Milan. Both teams finished second in the Eredivisie and the Serie A last season, qualifying automatically for the League Phase of the Champions League. While the Amsterdam giants exited the Europa League early last term, Inter Milan's European run took them to the finals of the Champions League, where they were thrashed 5-0 by the eventual winners PSG. Ajax has started the new domestic season well with three wins from five games so far, while Inter is yet to get into any rhythm. The Nerazzurri are the bookmakers' favorites.
Bet on Ajax vs Inter Milan with Bet365
Ajax vs Inter Milan Match Details
- Date: Wednesday, September 17, 2025
- Time: 21:00 CEST
- Venue: Johan Cruyff Arena, Amsterdam
Where to Watch Ajax vs Inter Milan Live on TV or Stream
| Country | TV Channel/Stream |
|---|---|
| UK | TNT Sports |
| US | Paramount+, CBS Sports |
| Canada | DAZN |
| South Africa | Supersport |
Ajax vs Inter Milan Match Preview
Ajax: form and statistics
Dutch giants Ajax are unbeaten in the Eredivisie this season, winning all three of their home games and drawing the two away games. They beat Zwolle 3-1 last weekend ahead of the midweek European clash. Ajax reached the semifinals of the 2019 Champions League, but has since not made it out of the group stages. Last year, they were knocked out of the Europa League in the Round of 16. New coach John Heitinga, a former player, is tasked with bringing silverware back to the club, as the club is on a three-year trophy drought. His side is yet to lose, although they are already trailing rivals PSV in the standings.
Ajax possible starting lineup:
Jaros; Gaael, Itakura, Baas, Wijndal, Regeer, Taylor, Klaassen, Berghuis, Weghorst, Godts
Bet on Ajax vs Inter Milan with Bet365Inter Milan: form and statistics
Inter will arrive in Amsterdam still smarting from a late collapse in the Derby d'Italia. Leading 3-2 up to the 80th minute, the Champions League finalists contrived to lose 4-3 against Juventus. Inter's sensational run to the finals of the 2024-25 Champions League included an impressive victory over favorites Barcelona in the semifinals, but a 5-0 spanking in the showpiece finale led to the exit of Coach Simone Inzaghi. Christian Chivu's side have one win and two losses in Serie A. Inter has a head-to-head advantage over Ajax.
Inter possible starting lineup:
Sommer; Akanji, Acerbi, Bastoni, Dumfries, Barella, Calhanoglu, Sucic, Dimarco, Thuram, Martinez
Ajax vs Inter Milan Match Prediction
Inter will love to make a statement in Amsterdam, to signal their intent for another push for the Champions League trophy. Ajax are happy to be back with the big boys, where they truly belong, and will feel that they have a chance against an Inter side that is low in confidence. We predict a high-scoring affair that will return over 2.5 goals.
Ajax vs Inter Milan Betting Odds
| Bookmakers | Over 2.5 | Over 3.5 |
|---|---|---|
| Bet365 | 1.57 | 2.37 |
| 1xbet | 1.653 | 2.4 |
| Betway | 1.51 | 2.23 |
