Detroit Tigers vs Chicago White Sox Prediction: Sox’s will struggle this time

Detroit Tigers vs Chicago White Sox Prediction and Odds on the Match on September 06, 2025

At Comerica Park, the Detroit Tigers will play the Chicago White Sox in a Major League Baseball encounter. This is the opener of a three-game series. The Detroit Tigers have been tagged favourites heading into this opener while Chicago White Sox are underdogs despite their recent incredible run. How will this game unfold? Below are full game previews and betting possibilities to consider. 

Detroit Tigers: Form and Statistics

The Detroit Tigers have not had an easy run heading into this fixture and will look to turn the tables here. In their recent series, this team played the Oakland Athletics, Kansas City Royals and New York Mets and won only one. In the game against the Athletics, this team suffered a sweep, scoring nine runs while conceding 22. Meanwhile, Detroit Tigers needed a 0-5 win in their finale of the series against the Kansas City Royals after the Royals evened it in game two. However, their last series to this game saw them lose to the New York Mets with the first two games ending 8-10 and 5-12 before a 6-2 finale to turn things around. Ahead of this game, the Detroit Tigers have an 81-60 record overall this season but a 3-7 record in their last ten games.

Detroit Tigers Team News and Lineup

Jack Flaherty will get the ball for the Tigers in this game. This season, Flaherty has been inconsistent with his record standing at 7-13. He had an average earned runs of 4.74 in that run with 1.29 WHIP over 142.1 innings pitched.

Detroit Tigers Expected Lineup

Colt Keith (L) 3B, Gleyber Torres (R) 2B, Kerry Carpenter (L) DH, Riley Greene (L) LF, Spencer Torkelson (R) 1B, Wenceel Pérez (S) RF, Zach McKinstry (L) SS, Javier Báez (R) CF, Jake Rogers (R) C

Chicago White Sox: Form and Statistics

The Chicago White Sox enter this game in high spirits and will look to take something out in this opener. After a run of games that saw them lose five straight games against the Kansas City Royals and New York Yankees, this team has now gone to win each of their last games. Against the Minnesota Twins in their last series, the Chicago White Sox completed a sweep in what was a four-game series. In the opener, the Chicago White Sox needed a one run win before a 3-12 and 3-4 win in the next two games. Meanwhile, their finale ended 8-11 with five runs in the seventh inning to redefine the game after the Twins had taken the lead. Ahead of this game, the Chicago White Sox have a 53-88 record and sit bottom of the American League with a 0.376 PCT. 

Chicago White Sox Team News and Lineup

Chicago White Sox will send Shane Smith to get the ball in this opener. Smith has a 4-7 record this season with a 3.81 average earned runs and a 1.20 WHIP over 120.1 innings pitched.

Chicago White Sox Expected Lineup

Edgar Quero (S) DH, Kyle Teel (L) C, Lenyn Sosa (R) 1B, Colson Montgomery (L) SS, Curtis Mead (R) 3B, Andrew Benintendi (L) LF, Chase Meidroth (R) 2B, Brooks Baldwin (S) RF, Michael A. Taylor (R) CF

Detroit Tigers vs Chicago White Sox Betting Tips & Odds

• In recent games involving the Chicago White Sox and other teams, the final game has ended over three times in their last four games. Also, each of Detroit Tigers last three games have ended with at least eight runs with two others ending with at least 17 runs. This game clearly has potential of ending with high runs with over 7.5 valued at 1.66 on Betway.
• Detroit Tigers have now scored at least five runs in each of their last four games into this fixture. The bookies tagged the hosts 5 runs at 1.85 on 1Xbet.
• Chicago White Sox despite being tagged underdogs have won twice in the last four games they played against the Detroit Tigers. Also, the visiting team is on a hot form with five consecutive victories heading into this game. 1Xbet offers a 2.58 odds for their moneyline option.
• The Detroit Tigers have struggled lately and heading into this game, they will look to make amends to their poor run. Also, the home team has been favoured while also having the better record in this fixture. A moneyline win has a 1.50 odds on Bet365.

Detroit Tigers vs Chicago White Sox Match Prediction 06 September 2025

The Chicago White Sox have surely been impressive in their last game but this is a tougher encounter to deal with. While the visitors have struggled all season, it is very difficult to trust them in matches like this especially after only picking 53 all season. Meanwhile, a sweep over the Minnesota Twins might be a momentum, but considering the level of class in this Detroit Tigers side, I believe they will need to do more than ordinary to get things right here. Meanwhile, the Detroit Tigers are also struggling to maintain consistency but coming into this game as favourites shows they are well above the Chicago White Sox. Yet, I believe this game will be very competitive with the White Sox giving a lot of trouble offensively. Therefore, with the Detroit Tigers being the better team, a moneyline win with high runs are feasible options to consider.

Our match prediction is a moneyline win for the Detroit Tigers and over 6.5 runs with odds at 2.10 on 1Xbet bookmaker. 

Our betting tip is over 8.5 runs with odds at 1.95 on Bet365 bookmaker. 

Our final match prediction is the Chicago White Sox over 3.5 runs with odds at 2.00 on Betway bookmaker.