Borussia Dortmund vs Bayer 04 Leverkusen Prediction: The Culling Continues.

Borussia Dortmund vs Bayer 04 Leverkusen: Prediction for the Match on December 02, 2025

The Round of 16 of the German Cup, the DFB-Pokal, kicks off, and Borrusia Dortmund will lock horns with Bayer Leverkusen at the Signal Iduna Park, the largest stadium in Germany.

Of the sixteen teams remaining in the tournament contention, thirteen are in the 1. Bundesliga, while three teams, Hertha FK, FC Kaiserslautern, and FC Magdeburg.

While the Dortmund-Leverkusen match is not considered a traditional derby, it has earned a reputation for being a high-stakes, winner-takes-all contest. The last clash between these teams was in the twelfth round of the 1. Bundesliga, at the BayArena in Leverkusen, which Dortmund won with a 2-1 score at full-time.

A preview of the game team statistics, emerging lineup, and several betting options are available below.

🏠 Borussia Dortmund: Form and Statistics

Last Five Matches: WLWWL

League: 1. Bundesliga

League Position: 3rd

Goals Scored (Cup): 2

Goals Conceded (Cup): 1

A slim opening against Essen in the DFB Pokal raised doubts about the Prussians' intentions for their silverware, which worsened in the second-round contest against Eintracht Frankfurt, a game that saw Dortmund take due advantage of the penalty shootout after the 1-1 score in normal time. The game, played at the Deutsche Bank Park, saw the Eagles of Frankfurt (Die Adler) open the scoring in the first seven minutes, courtesy of Anagar Knauff, who gave his team the early advantage. The advantage thrived till the end of the first half, but was quickly overturned three minutes after the first half, when Dortmund’s Julian Brandt equalled the scales - a goal which kept the scoreline at parity till the penalty shootout culled the sheep from the goats.

So far, none of Dortmund’s games in the German Cup have seen them win without a close contest. Although Niko Kovac has a game against Hoffenheim on the seventh, it is expected that the Black and Yellows advance from this round to face whoever emerges victorious between FC Kaiserslautern and Hertha Berlin. Therefore, they must put their best foot forward.

🏁 Borussia Dortmund: Lineup

Credence must be allotted to Karim Adeyemi, who has scored in three consecutive matches after his return from injury. He scored the final goal in the 3-3 game against Stuttgart, the third goal in the 4-0 contest against Villarreal in the UEFA Champions League Competition, and the winning goal in the 2-1 match against Bayer Leverkusen last week. Maximilian Beier is back in training and could return to the squad while Niklas Sule is away due to injury.

🔖 Predicted Lineup (4-1-3-2): Kobel, Schlotterbeck-Anton-Anselmino, Svensson-Sabitzer-Nmecha-Ryerson, Brandt-Adeyemi, Guirassy

👤 Head Coach: Niko Kovac

⛔ Out: Niklas Sule

✈️ Bayer O4 Leverkusen: Form and Statistics

Last Five Matches: WLWLW

League: 1. Bundesliga

League Position: 4th

Goals Scored (Cup): 8

Goals Conceded (Cup): 2

Bayern Leverkusen’s clean sweep in the Cup tournament has been outstanding, with eight goals scored in two rounds. The opener against Dynamo Dresden was colorful for the side that seized the day with a flat-out 4-0 victory.

Round 2 was a bit tougher for the side that forced their way through Paderborn’s defences to eventually secure a 4-2 win, propelling them to the Round of 16. Many report that this will be Leverkusen’s first real test, partly because they were recently beaten in their league game against Dortmund, which ended in a 2-1 loss last week, despite home-field advantage at the BayArena.

🏁 Bayer 04 Leverkusen: Lineup

Leverkusen will play against Dortmund without Lucas Vasquez, who is sidelined due to fitness concerns. Ezequiel Fernandes and Exequiel Palacios will also be considered as doubtful for this game as they await the nod from the team’s medical staff to resume training.

🔖 Predicted Lineup (4-2-3-1): Flekken, Tapsoba-Bade- Quansah, Grimaldo-Maza-Garcia-Hofman, Poku-Tillman, Kofane

👤 Head Coach: Kasper Hjulmand

⛔ Out: Injury-Lucas Vasquez, Doubtful-Ezeqiel Fernandes, Exequiel Palacios

🤝Borussia Dortmund vs Bayer 04 Leverkusen Head-to-Head Statistics

Ten recent meetings between these sides have produced two wins for Bayer 04 Leverkusen, two stalemates, and six wins for Borussia Dortmund.

📈 Borussia Dortmund vs Bayer 04 Leverkusen Match Betting Trends

The BTTS - Yes: The last five meetings between the sides have resulted in a BTTS- Yes outcome. Consider the same at 1.50 odds from Betway

Dortmund to score two goals: Dortmund has scored two goals in the last three meetings between the sides. 1xbet tips this betting tip at 1.66 odds.

The O 2.5 goal option: The last three meetings between the sides produced at least three goals. Bet365 tips this pick at 1.53 odds.

🎯 Borussia Dortmund vs Bayer 04 Leverkusen Match Prediction 02 December 2025

Borussia Dortmund has always been a challenging team for Bayer Leverkusen to defeat, with the last five clashes seeing Dortmund unbeaten in four matches, resulting in two wins and two stalemates. Despite all these, one variant we can always count on whenever the teams come toe-to-toe is goals from both sides. The two sides will score, there will be no penalties, and the goals will not be more than three.

Below are my best predictions:

🔥 Our initial prediction is that Dortmund scores two goals at 1.66 odds from 1xbet

🔥 Our prediction is that Dortmund wins at 1.80 odds from the Bet365 bookmaker

🔥 Our final prediction will be for U 3.5 Goals at 1.61 odds from Betway