Internacional vs Grêmio Prediction: Grenal 448

Internacional vs Grêmio: Prediction and odds on the Brasileirão match on September 21, 2025

The two rivals from Porto Alegre will clash in the derby under enormous pressure due to poor results. Both coaches risk being sacked in the event of defeat.

Internacional: Form and statistics

Internacional lost 4-1 to Palmeiras away from home, deepening its crisis. The Gaúchos had a disastrous first half and were already losing 4-0 at halftime. Inter's defense was unable to stop Vitor Roque, who scored three goals. Roger Machado corrected some positioning problems, and the second half was more balanced. In one of the few times that Inter reached Palmeiras' goal, Carbonero reduced the deficit to 4-1 in the 72nd minute. The Colorado avoided humiliation, but Roger Machado's position is at risk, and the Grenal will likely decide the coach's future. A victory over Grêmio could save Roger Machado, at least temporarily. Internacional finished fifth last year, but this year occupies 12th place with 27points, just five above the relegation zone.

Internacional: Lineup

Bernabei is back after being suspended. Borré has been out for the last few games due to injury, but could be fit for the derby. Roger Machado may change the tactical system and adopt a backline with three defenders.

🔖Internacional starting lineup (3-5-2)

Rochet – Vitão, Mercado, Juninho – Aguirre, Thiago Maia, Bruno Henrique, Alan Patrick, Bernabei – Borré, Carbonero

⛔️Out: Ronaldo, Ivan, Bruno Gomes (injured) 

👤Head Coach: Roger Machado

Grêmio: Form and statistics

Grêmio's situation is not very different from that of its rival, Inter. The Immortal is in 14th place with 25 points, and Mano Menezes is also being heavily criticized. Menezes was almost fired a month ago, but a win against Atlético Mineiro in Belo Horizonte saved the veteran coach. In the last round, Grêmio lost 1-0 at home to Mirassol, and the instability returned. The club made several signings in this transfer window, including Arthur and Willian, two players with extensive experience in Europe. Arthur played with Mirassol, and Willian is expected to make his debut against Inter. Grêmio urgently needs points as it is very close to the relegation zone. A victory over the rival could mark a turning point in the season, but it will not be easy.

Grêmio: Lineup

Forward Braithwaite suffered an Achilles tendon injury and will not play again this season. The Danish player has joined a long list of injured players. Center back Kannemann will miss the derby after receiving his third yellow card in the last game.

🔖Grêmio starting lineup (4-3-3)

Volpi – Marcos Rocha, Noriega, Wagner Leonardo, Marlon – Dodi, Arthur, Cuéllar – Willian, Alysson, Carlos Vinicius

⛔️Out:  Braithwaite, Balbuena, Riquelme, Camilo, Villasanti, João Lucas, Monsalve, Ely (injured), Kannemann (suspended)

👤Head Coach: Mano Menezes

Internacional vs Grêmio: Head-to-head statistics

Internacional and Grêmio have met 447 times, with Inter holding the upper hand. The Colorado won 165 matches, while the Immortal won 141. On 141 occasions, the Grenal ended in a draw. This season, the two clubs have already clashed four times, once in the league and three times in the Campeonato Gaúcho. It is worth noting that Grêmio has not defeated Internacional in eight matches.

Internacional vs Grêmio: Betting tips & Odds

• Internacional has conceded first in five of its last six games. You can bet that Grêmio will be the first team to score for 2.60 at Bet365;
• The TU 2.5 bet has won five times in Grêmio's last six matches. You can bet on a game with less than three goals scored (TU 2.5) for 1.68 at 1xBet;
• The BTTS-YES bet has won 10 times in Inter's last 12 matches. You can bet on both teams to score (BTTS-YES) for 2.00 at Betway.

Internacional vs Grêmio match prediction 21 September 2025

Both teams are having a season to forget, but even so, this is one of the most fiercely contested derbies in the world. Only two points separate Internacional and Grêmio in the table, but the two rivals are not far from the relegation zone. Both coaches are at risk of being fired, and whoever loses will likely leave the club. There are no favorites in the Grenal 448, so I'm going to risk a draw.

Our match prediction: Draw for 3.50 at Bet365.

Our betting tip for this Brasileirão match: TU 2.5 for 1.68 at 1xBet.

Our final betting tip on the match: Correct Score 1-1 for 6.50 at Betway.