Santos FC vs Sao Paulo Prediction: Neymar Jnr Absence May Cost Santos As Sao Paulo Show Better Promise In This San-Sao Derby

Santos FC vs Sao Paulo: Prediction for the Match on September 22, 2025

Prediction for the Brasileiro Betano game between Sao Paulo and FC Santos, live at the Estádio Urbano Caldeira ahead of the 22nd league round. This will be the third time Neymar Jnr misses the derby against Sao Paulo, with Oscar taking his place. A preview of the game team statistics, emerging lineup, and several betting options are available below.

🏠 Santos FC: Form and Statistics

Last Five Matches: WLLDD

Struggling not to steer off the path of consistency, Santos FC has managed to rake in five points from the last five league encounters - courtesy of one win, two losses and two stalemates. Comprehensive analysis indicates difficulty for the side to shake off the 6-0 home loss against Vasco da Gama, with a follow-up 2-nil defeat against Bahiaco.However, subsequent weeks have seen the side manage to save face in consecutive stalemates against Fluminense (0-0) and Atletico Mineiro (1-1). Santos had real defensive problems, and save the dying-minute penalty awarded, they would have lost against Mineiro.

So far, they have lost eleven of twenty-two league games, with six wins and five stalemates.

🏁Santos FC: Lineup

Santos’s defensive problems were aired out last week against Atletico Mineiro, and whether it stays a fact or not, they are bound to suffer greatly against Sao Paulo. A couple of names are expected to be off the list for the starting XI. Neymar will miss the San-Sao meeting for the third consecutive time, following a light knock picked against Mineiro. Benjamin Rollheiser’s double-yellow will also see him miss this game.

Tiquinho Soares and Oscar will most probably fill Neymar and Diaz’s attacking spots.

Predicted Lineup (4-4-2): Brazao, Escobar-Peres-Ivaldo-Vinicius, Guilherme-Rafael-Schmidt-Hugo, Oscar-Soares

Head Coach: Juan Pablo Vojvoda

⛔ Out: Joao Bassao (Doubtful to start), Willian Arao (Injured), Benjamin Rollheiser(Suspended)

✈️Sao Paulo: Form and Statistics

Last Five Matches: WDWLW

A bit more stable on their tracks, Sao Paulo’s persistence has seen them accumulate nine wins and eight stalemates in twenty-three matches. The recent 1-nil victory over the troublesome Botafogo side was indeed commendable, with the delighted fans proud for such a comeback, considering the previous 1- nil wash-down against Cruzeiro.

Across the board, the onus for victory is long overdue, with the side showing poor performances in the CONMEBOL Libertadores and crashing out of the Copa do Brasil after a 3-nil aggregate against Athletic.

Sao Paulo currently occupies the seventh league spot, with a latent premonition to leap off their Sudamericana positioning while gunning hard for a decent spot in the Libertadores.

🏁Sao Paulo: Lineup

The team is expected to lay a severe chokehold in the midfield with five free roamers. Cedric Soares does an excellent job in the flanks, with his intermittent linkups with Tapia in quick getaways also an admirable aspect of their play. Hernan Crespo faces big problems, with Lucas Moura, Luiz Gustavo and other respected names off the list due to fitness problems

🔖 Predicted Lineup (3-4-1-2): Rafael, Sabino-Franco-Toloi, Diaz-Maia-Alisson-Soares, Rodriguinho-Dinneno-Tapia

👤 Head Coach: Hernan Crespo

⛔ Out: Injured - Luiz Gustavo, Lucas Moura, Oscar, Lucas Ferreira, Andre Silva. Suspended: Bobadilla, Luciano

🤝Santos FC vs Sao Paulo Head-to-Head Statistics

The most recent ten games between the sides has produced five wins for Sao Paulo, three wins for Santos FC and two stalemates.

📈 Santos FC vs Sao Paulo Betting Trends

Santos scoring Against Sao Paulo: Santos has scored against Sao Paulo in the last three meetings. Consider at least a goal for Santos at odds from 1xbet.

Goals: The last two San-Sao meetings produced at least two goals. Bet on the O 1.5 goal rating at 1.51odds from Betway.

Santos Goal Difficulty: Santos has scored more than two goals in the last six games. Consider the Santos Under 2.5 goals at 1.52 odds from 1xbet

The BTTS Trend: The last two San-Sao meetings also produced goals on both ends. Consider this choice at 2.17 odds from Betway.

🎯 Santos FC vs Sao Paulo Match Prediction 22 September 2025

The San-Sao derby clash has given one of the most exciting pitch contests in the Brazil Serie A, and this fixture feels no different. Santos will try to avoid a loss to Sao Paulo, who are lacking a great number of key players. Depending on how feisty the two sides push, this game has all the markings of a stalemate.

Below are my best predictions:

🔥 My prediction is for a first half stalemate at 1.90 odds from Betway

🔥 The betting tip here will be for an Away/Draw at 1.65 odds from 1xbet

🔥 Lastly, I will consider the BTTS-NO option at 1.66 odds from Bet365