LDU Quito vs São Paulo Prediction: LDU aims to leverage home advantage in the Copa Libertadores quarterfinal

LDU Quito vs São Paulo: Prediction and odds on the Match on 19 September 2025

São Paulo will travel to Ecuador in a crucial Copa Libertadores clash at the Estadio Rodrigo Paz Delgado, with LDU aiming to get the home advantage. São Paulo, sitting 7th with 35 points, is coming off a 1-0 victory over Botafogo and aiming to continue their perfect and unbeaten record in the Libertadores. 

LDU Quito, on the other hand, finished top of Group C with only a single loss from the six group games played. They remain third placed in the Ecuadorian league, and in the right place for a Copa Libertadores qualification next season. This game is a very important one, and the teams will not throw caution to the wind in their performance on Thursday. São Paulo’s biggest challenge, however, lies in their growing injury list, which has stretched the squad thin. Historically, it's always a tough fight whenever these teams meet, and we are led to expect a very tough encounter here. Check the team conditions! Several betting options are available.

LDU Quito: form and statistics

Form in all competitions: WDLWD

LDU Quito find themselves in a bit of a fix, with two wins in their last five league games across competitions. They come to this game on the back of a 0-1 victory over Libertad in their last league game. They remain firmly in third place in the Liga Pro, with 13 wins, 9 draws, and 6 losses from 28 games played.

In the Copa Libertadores, LDU Quito impressed in the group stage, topping Group C with 3 wins, 2 draws, and just a single defeat. They found the net 8 times and conceded only 4 goals across those six games. However, they bounced back to win their round of 16 clash after losing to Botafogo in the first leg, via Guimarães’ lightning-fast first-minute strike in Brazil. The magic happened in Ecuador, where LDU Quito won by 2 goals to nil to secure their qualification to the quarterfinals. 

Back at home, LDU Quito is a different beast. Their record at the Estadio Rodrigo Paz Delgado this year has been flawless, with no team managing to beat them on their own turf. Defeating Sao Paulo won’t be easy, but if there’s a place they can pull it off, it’s at home.

LDU Quito: Lineup

Pablo Andres Sanchez needs his best team for this game, and some players were rested over the weekend just for this game. Pablo Sanchez likes to use two forwards up front. Alex Arce has scored four goals so far for LDU in the Copa Libertadores. Richard Mina was sent off in the return leg against Botafogo, and he won't be available for this fixture.

Player to watch out for: Alex Arce

30-year-old forward Alex Arce is the team's current top scorer in the Copa Libertadores with 4 goals to his name. He also has three goals in the League. 

🔖LDU Quito starting lineup (3-4-1-2)

Gonzalo Valle– Leonel Quinonez, Ricardo Ade, Dario Aimar, — Carlos Gruezo, Quintero, Enrique, Cornejo — Bryan Ramirez, Lisandro Alzugaray, – Michael Estrada, 

⛔️Out: Richard Mina

👤Head Coach: Pablo Andres Sanchez 

São Paulo: form and statistics

Form in all competitions: WLWDD

The Tricolor Paulista bounced back from that 1-0 loss to Cruzeiro with a victory in their last league game. The victory was against their arch-rivals, Botafogo, and it ended in a narrow 1-0 win to Sao Paulo, with Dinenno scoring the lone goal in the 7th minute. São Paulo remains a formidable force, winning six of their last seven on home soil. Currently sitting seventh with 35 points, they are level on points with sixth-placed Botafogo, while trailing eighth-placed Red Bull Bragantino. 

While their Copa do Brasil journey ended at the hands of Athletico, the bigger focus now shifts to securing Copa Libertadores football for next season. For a club with São Paulo’s history, that’s non-negotiable. And with a massive quarter-final clash against LDU Quito looming around the corner, the Tricolor Paulista know they have to sharpen up fast if they’re going to deliver both at home and on the continental stage.

São Paulo: Probable Lineup

Forward Andre Silva, who has been on fire for Sao Paulo in the Copa Libertadores with three goals to his name in the competition, suffered a serious knee injury and is most likely ruled out for the rest of the season. A major problem facing Hernan Crespo is their long list of injuries. With Andre out of the season, Ferreira is most likely to replace him up front.

Player to watch out for: Ferreira

With almost half the squad injured, Ferreira remains the man to watch out for in this São Paulo side. The 27-year-old forward has 4 goals and two assists in the league this season. 

🔖 São Paulo probable starting lineup (3-4-1-2)

Rafael— Franco, Sabino, Ferraresi— Cedric Soares, Pablo Maia, Alisson, Enzo Diaz— Rodriguinho— Gonzalo Tapia, Ferreira.

⛔️ Out: André Silva, Marcos Antônio, Lucas Moura, Arboleda, Ryan Francisco, Oscar, Calleri, Luiz Gustavo (injured). 

👤 Head coach: Hernan Crespo 

LDU Quito vs São Paulo: head to head statistics

The teams met twice in the 2020/21 Copa Libertadores Group D, and Sao Paulo won by a 5-4 aggregate score. A 3-0 victory in the first leg for Sao Paulo, and a 4-2 home win for LDU in the return leg. They met again in the quarterfinals of the Copa Sudamericana in the 23/24 season, with LDU advancing to the semifinals on penalties after a 2-2 aggregate draw across both legs. 

LDU Quito vs São Paulo: Betting Tips & Odds

• LDU has not kept a clean sheet in their last four meetings, and the option for Sao Paulo to score is offered on the BetWay bookmaker website for odds of 1.73;
• There has been a total of over 2.5 goals in three of their last four meetings, and the option for a total of over 2.5 goals in this game is offered on the Bet365 bookmaker website for odds of 2.52;
• There has been a minimum of two goals in three of their last four meetings, and this option is offered in the 1xBet bookmaker at 1.92 odds;

LDU Quito vs São Paulo match prediction 19 September 2025

This clash has all the makings of a cracker. LDU Quito has not lost a game at the Estadio Rodrigo Paz Delgado this season, and it will take a miracle for Sao Paulo to break LDU’s unbeaten run on their home ground. São Paulo has a huge task on their hands. São Paulo, on the other hand, remains a very solid team offensively and defensively, but their growing list of injuries remains a major concern. We can bank on a win or draw for LDU while also expecting goals from both teams.

Our match prediction is a total of over 2.5 corners for Sao Paulo for a coefficient of 1.62 in the 1xBet bookmaker.

Our betting tip on the match is a win or draw for LDU Quito and a total of over 1.5 goals for a coefficient of 1.80 in the Betway bookmaker.

Lastly, a total of over 0.5 goals for Sao Paulo for 1.76 odds in the Bet365 bookmaker.