Independiente vs Universidad de Chile Prediction for the Match on August 21, 2025

Independiente vs Universidad de Chile: Prediction and odds on the Match on 21 August 2025

Two South American sides clash in the Copa Sudamericana 2025 Round of 16 as Independiente de Avellaneda hosts Universidad de Chile at the Libertadored de America for the return leg of their round of 16 clash. Universidad de Chile heads into this game with the advantage after Lucas Assadi’s 36th-minute strike gave them the all-important lead in the first leg. Independiente de Avellaneda heads into this clash on the back of a 2-1 defeat to Velez Sarsfield in the Argentine Liga Profesional, and their woes might continue on their home ground on Thursday. The visitors remain our favorite for the win, and they should get the victory here. Check the team conditions! Several betting options are available.

Independiente: form and statistics

Form in all competitions: LLDLL

The Argentinian side is the direct opposite of their opponents, Universidad de Chile. Independiente are struggling, winless in their last seven games across all competitions, including two consecutive losses in their last two league games, with the defeat against Velez Sarsfield being the most recent. In the Argentine Primera División, they languish at the bottom of their league with two draws and three losses from five games, scoring just four goals and conceding seven. Their home form is a big concern, with no wins in their last two home games, and it leaves us to worry about their survival for Thursday's encounter against Universidad de Chile. 

In the Copa Sudamericana, they made good strides throughout their time in Group A, finishing top of Group A with a total of 16 points earned from a possible 18, with four wins and two losses. They even scored the most goals in the Group with 16 goals scored and 6 conceded. However, they were met with fierce opposition in the round of 16 against Universidad de Chile, who defeated them in the first leg. Independiente had a great game in that match, creating several big chances, but they failed to convert them into goals. Matias Abaldo was sent off in the 73rd minute after receiving his second yellow card, and he won't be available for Thursday’s return leg clash.

Independiente Lineup

Universidad de Chile Lineup

Coach Julio Vaccari faces challenges with Federico Vera and Luciano Cabral doubtful. Gabriel Ávalos’ goal threat and Federico Mancuello’s creativity are also needed to orchestrate plays from the midfield. Matias Abaldo will not be available after his red card in the first leg. Julio Vaccari will either change his formation or look for another point man for Thursday’s encounter.

Player to watch out for: Diego Tarzia

The 34-year-old striker has three goals and two assists in the Sudamericana and is favored to score. He played all six group stage games in the Sudamericana, and he will be ready to make his mark on Thursday. 

🔖 Independiente starting lineup (4-2-3-1)

Rodrigo Rey– Federico Vera, Kevin Lomonaco, Nicolas Freire, Facundo Zabala– Felipe Loyola, Rodrigo Fernandez, – Santiago Momtiel, Luciano Cabral, Walter Mazzantti – Ignacio Pussetto 

👤Head coach: Julio Vaccari 

Universidad de Chile: form and statistics

Form in all competitions: LWWLW

Universidad de Chile has been in strong form, losing only three games in their last eleven games across all competitions. Their domestic form is quite incredible, as they are second-placed in the Chilean league with 12 wins, two draws, and four losses from a total of 18 league games played. Their last league game was a disaster for Universidad de Chile as they suffered a 1-3 loss to Audax Italiano. This defeat could be because of the imminent return leg of the Copa Libertadores against Independiente, causing manager Gustavo Alvarez to rest some of his key players.. 

Universidad de Chile crashed out of the Copa Libertadores after finishing third in Group A, amassing just 10 points from a total of 18. They secured three wins with a draw, and two losses. Their third-place finish in Group A earned them a playoff spot against Guarani, which they took by the horns and annihilated Guarani in a 6-2 aggregate. 

Assadi has been a force to be reckoned with at Universidad de Chile in the South American competition, with three goals to his name so far in the competition. He scored the only and winning goal in the first leg against Independiente. Overall, the team has been solid this season both domestically and otherwise, and we are looking forward to an improved Universidad de Chile side on Thursday.

Universidad de Chile Lineup

Álvarez’s 4-2-3-1 leverages Assadi’s flair and Lucas Di Yorios’ finishing, with Charles Aránguiz anchoring midfield. Assadi proved himself once again, scoring the only goal in their narrow 1-0 win over Independiente on Thursday.

Player to watch out for: Lucas Assadi

The 21-year-old forward has been electric, scoring three goals in the Copa Sudamericana this season.

🔖 Universidad Del Valle starting lineup (4-4-2)

Castellón – Calderón, Nicolas Ramirez, Salomoni, Zaldivia – Poblete,Charles Aranguiz — Fabian Hormazabal, Javier Altamirano, Lucas Assadi — Lucas di Yorio

👤 Head Coach: Gustavo Alvarez 

Independiente vs Universidad de Chile: head to head statistics

This is the second-ever meeting between the two teams. Universidad de Chile won the first leg, and I believe they will advance to the quarterfinals.

Independiente vs Universidad de Chile: Betting Tips & Odds

• No wins for Independiente in their last 7 meetings, and the option for Independiente to lose this game is offered on the 1xBet bookmaker website for odds of 5.25;
• More than 2.5 goals in 6 of Universidad de Chile’s last 7 games, and this option is available on the Betway bookmaker website at 2.07 odds;
• Independiente has conceded first in 5 of their last 7 games, and this option is available on the Bet365 bookmaker website at 3.10 odds;
• Some experts believe that Independiente will win because of their near-perfect record in the Copa Sudamericana, and this option is offered in the Bet365 bookmaker at 1.66 odds;

Independiente vs Universidad de Chile match prediction 21 August 2025

Universidad de Chile is in impressive form, and their attack, led by Assadi and Lucas di Yorio, gives them a slight edge. Independiente is a shadow of itself with a very bad record in their last seven games across all competitions. All pointers lead to a win or draw for Universidad de Chile, and we will align with that prediction. Our first prediction is a win or draw and a total of over 1.5 goals for Universidad de Chile. Another prediction will be for Universidad de Chile to score first, as their opponents, Independiente, are very bad defensively at the moment and have conceded a goal first in five of their last seven games. Lastly, we might see a goal from the hosts due to their impressive form in the Group stage of the Sudamericana, and the advantage of their home fans. 

Our match prediction is a Universidad de Chile to score at least a goal for a coefficient of 1.71 in the 1xBet bookmaker.

Our betting tip on the match is a win or draw for Universidad de Chile for a coefficient of 2.23 in the Betway bookmaker.

Lastly, both teams to score for 2.00 odds in the Bet365 bookmaker.