Prediction and betting tips on the Lille OSC vs Olympique Lyonnais match 28.09.2025: match preview, lineups, odds for the game.

Lille
Lille
Start
Day
Hours
Minutes
Seconds
Finished
Live
28 Sep 2025 18:15
FC Lyon
FC Lyon
Football: France, Ligue 1
Stadium: Decathlon Arena; Stade Pierre Mauroy
⏰Time: 28/08/2025; 18:15
Braimoh Usman Daniel
25 Sep 2025
15:54
Statistics of the month:
26
22
0
54.17%
Statistics
Odds
Bet Type
Bookmaker
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Odds 1,61
Bet Type Lyon Win +1 Handicap
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Lille vs Olympique Lyonnais: Prediction for the Match on September 28, 2025

Prediction for the contest between LOSC Lille Metropole and Olympique Lyonnais as the sixth round of the French Ligue 1 goes underway. This will be one of the most anticipated fixtures this week, with two top-table teams vying for maximum points and table domination.

Below is a preview of the team news, emerging line-ups, Head to head comparison, several betting trends and expert predictions are available below.

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Last Five Matches: DWWWL

An almost flawless five-game run was ruined by RC Lens last week, in the 3-nil away defeat that ticked as their first loss of the season - an interesting highlight. Lille’s 7-1 conquest in the third matchweek against Lorient, which currently tops as the most embarrassing victory this season - marking another highlight for the team. A 3-3 season opener against Stade Brest, a refulgent 1-nil victory against AS Monaco, and an excellent 2-1 showing against AS Monaco in the fourth week.

The most recent league matches for Les Dogues has produced three wins, one stalemate and one loss, raking ten points, with a 13:8 goal-difference statistic.

Lille’s defeat against RC Lens exposed the lapses created by the absence of some of their main players. Thomas Meunier, Calliard and Ribeiro are on the sidelines from injury stints. Perraud, whose fitness status previously gave subtle doubts, has been cleared to join the starting XI. A couple of regular names are still missing from the line-up and Bruno Genesio, Head Coach of the squad is expected to still search for means to maximize home advantage, as a consecutive loss could jeopardize their league table standings.

Predicted Lineup (4-2-3-1): Ozer, Perraud-Mbeba-Ngoy-Mandi, Bouaddi-Bentaleb, Correia-Haraldsson-Fernandez- Giroud

Head Coach: Bruno Genesio

Out: Injury - Alexsandro Ribeiro, Marc-Aurele Calliard, Ousmane Toure, Thomas Meunier Doubtful:Perrard, Ugo Raghouber, Benjamin Andre

Recent Form: WWWLW

An astounding initial run of form ushered Olympique Lyonnais into the 2025/2026 season, with three wins in a row - The 1-nil opener against RC Lens, the 3-nil domination over FC Metz and the third 1-nil cap in the Choc des Olympiques, the game against Marseille.

Their blazing run of form flickered in the fourth matchweek, backtracking in the 3-1 away loss against Stade Rennes, in a game that saw everything go wrong, with the team finishing at full-time with ten men after conceding a red card. A quick turnaround however, was implemented in the 1-nil win against Angers F.C last week.

Olympique Lyon has had quite the run this season, with twelve points in the last five league matches having accrued four wins and one loss.

Nicolas Tagliafico and Maitland-Niles run flank affairs in the last lines, Corentin Tolisso holds the attacking tactical runs in coordination with Adam Karabec and Malik Fofana. Head Coach Liam Rosenior has a very quality-studded lineup prepped ahead of this clash. From the backlines to the attacking front, quality oozes. Remy Descamps and Abner Vinicius will be kept on the sidelines as they continue to convalesce from their fitness worries.

🔖 Predicted Lineup (4-2-3-1): Greif, MaitlandNiles-Mata-Diakhate-Tagliafico, Tessman-Merah,Karabec-Tolisso-Fofana-Satriano

👤 Head Coach: Liam Rosenior

Out: Doubtful- Remy Deschamps, Abner Vinicius

Ten recent pairings between Olympique Lyon and Lille have produced two (2) wins for Lille , three (3) stalemates and five wins for Olympique Lyon.

Lyon’s Recent Dominance: Olympique Lyon has recently held their prestige against Lille, either winning or forcing a stalemate. Consider the Away/Draw betting tip at 1.61 odds from Bet365.

Frequency of The BTTS outcome: The BTTS outcome has prevailed between the sides in the most recent four meetings. Betway tips this betting outcome at 1.63 odds.

At Least Two Goals In Each Meeting: The last seven direct clashes between the sides have produced at least two goals. Consider the O1.5 goal option at 1.24 odds from Betway.

Lille’s Consistent Scoring Against Lyon: Lille has consistently pushed a goal across Lyon last line in the last six meetings. Consider at least one goal for Lille at 1.19 odds from 1xbet

The Lille-Lyon clash has slowly become one of the fiercest league clashes in the Ligue 1, with the two sides pulling strings to entertain their fans and deliver value for their respective loyalties. Although recent H2H statistics has seen Lyon plant their feet as the more solid side, Lille’s streak of hat-trick wins in their season opening turned the spotlight toward their direction. Interestingly, we expect a clash of motives here, as Lille will look to rise from the ashes while Lyon sets their sights on a winning brace.

Of all teams in the Ligue 1, Lille plays the fiercest at home, and will look to give the visitors hell on the pitch. This will be the underlying variable of consideration in our choices for this contest.

Below are my best predictions:

🔥 Our main prediction is for a Lyon To Win with a One-Goal Handicap at 1.61 odds from Bet365

🔥 Our betting tip here will be Home Win, Or Draw and a Total of 1.5 goals at 1.72 odds from the 1xbet bookmaker.

🔥 Our final betting tip will be Under 10 Corners at 1.83 odds from Betway.

Odds
Bet Type
Bookmaker
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Odds 1,61
Bet Type Lyon Win +1 Handicap
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Odds 1,72
Bet Type 1X + 1.5
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Odds 1,83
Bet Type U 10 Corners
Bonus 250 USD
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