Mainz vs Hoffenheim Prediction: The Visitors are Struggling at the Mewa Arena

Mainz vs Hoffenheim: Prediction for the Match on November 21, 2025

High-flying Hoffenheim will aim to make it five straight Bundesliga wins when they travel to the Mewa Arena to lock horns with the struggling Mainz in the 11th round. Who's going to come out on top? Let us check out the match preview, team news, and betting odds to place your bets!

Mainz: Form and Statistics

Form: LDLLL

Very little has fallen in Mainz's favor this season, with the team second to last in the Bundesliga standings. Their struggles have been well-documented, largely due to their inability to close out games. Of the ten games they've played this season, one has resulted in a victory, and it came against Augsburg two months ago, with a 4-1 win on the road.

Before the international break, Die Nullfünfer were toothless in their Bundesliga match against Eintracht Frankfurt. The team suffered a 1-0 defeat on the road, with the underlying issue in that match being their poor display in the final third. They failed to register a single shot on target in the entire game from just one attempt.

Bo Henriksen's men will want to be more clinical this time around as they seek to end a six-match winless run in the league. This run consists of five losses and one draw. Another issue they need to address is their poor form at home this season. They are one of two teams yet to register a win after five games, along with Wolfsburg.

Mainz: Team News

Mainz will be missing three players for this upcoming encounter. The duo of Anthony Caci and Maxim Dal are in the injury room, recovering from thigh and knee injuries, respectively.

Maxim Leitsch has missed eight competitive games for his team due to illness. The 27-year-old centre back won't be available this Friday.

Nadiem Amiri has been the team's top goalscorer this season in the Bundesliga, scoring three goals and providing one assist. Adding numbers from other competitions, his record stands at seven goals and one assist from 17 matches. However, it has been a bit quiet for him, as he has gone four games across all competitions without contributing to a goal.

🔖 Probable Starting XI (3-4-2-1): Zentner; da Costa, Maloney, Kohr; Mwene, Amiri, Sano, Widmer; Nebel, Jae-Sung Lee; Hollerbach.

⛔️ Out: Anthony Caci (thigh injury), Maxim Dal (knee injury), Maxim Leitsch (illness).

👤 Head coach: Bo Henriksen.

Hoffenheim: Form and Statistics

Form: WWWWL

In contrast, Hoffenheim are riding a wave of momentum in the Bundesliga, with the team currently on a four-match winning streak. During this period, their offense stood out, scoring three goals in each of those victories.

Christian Ilzer's men played host to RB Leipzig in their last league game before the international break. Despite the odds stacked against them in that match, they managed to come out on top in a 3-1 victory.

Die Kraichgauer are on the road this time around. Suprisingly, they've performed much better in unfamiliar surroundings than at home. They are one of two teams in the league this season that have yet to taste defeat in five games, along with Bayern Munich.

Hoffenheim: Team News

Hoffenheim have no fresh injury concerns to worry about heading into Friday's clash with Mainz, aside from the regular two absentees, Valentin Gendrey, Koki Machida, and Adam Hlozek.

Fisnik Asllani has really stood out for Hoffenheim this season. He has been directly involved in seven goal involvements, scoring five and providing two assists. The 23-year-old also provided an assist in the previous game against RB Leipzig and will aim to make another impact in this one.

🔖 Probable Starting XI (4-4-2): Baumann; Bernardo, Hajdari, Hranac, Coufal; Toure, Avdullahu, Burger, Kramaric; Asllani, Lemperle.

⛔️ Out: Valentin Gendrey (snkle injury), Koki Machida (knee injury), and Adam Hlozek (foot injury).

👤 Head coach: Christian Ilzer.

Mainz vs Hoffenheim: Head-to-Head Statistics

In the last 34 meetings, Mainz have won 15 times, Hoffenheim have won 10 times, and there have been 9 draws. The goal difference is 59-51 in favor of Mainz.

Mainz vs Hoffenheim: Betting Tips & Odds

• Mainz have scored under 2.5 goals in each of their last six matches across all competitions. You can bet on under 2.5 Mainz goals for 1.19 at 1xbet.
• Hoffenheim have scored over 2.5 goals in three of their last five away Bundesliga games. You can bet on over 2.5 Hoffenheim goals for 4.65 at 1xbet.
• Mainz have scored the opening goal in four of their last five Bundesliga home matches against Hoffenheim. You can bet on Mainz to score first for 1.90 at Betway.
• Hoffenheim's Andrej Kramaric scored a brace against Mainz the last time they met. You can bet on Andrej Kramaric to get on the scoreboard for 3.00 at Bet365.

Mainz vs Hoffenheim Match Prediction 21 November 2025

Indeed, Mainz have the worst home record in the Bundesliga this season, but that doesn't mean they are not capable of causing an upset in this one. Their home record against Hoffenheim has been impressive as they are unbeaten in five games, including a four-match winning streak.

Hoffenheim are in high spirits at the moment and will want to snap that losing run against Mainz on the road. For this match, however, I expect both sides to score, with the total goals exceeding 2.5. The visitors' defense this season has not been convincing, conceding in nine of their last ten league games. The BTTS + Over 2.5 bet has also landed in each of their last three Bundesliga games.

Our match prediction: BTTS & TO 2.5 for a coefficient of 1.80 in the Bet365 bookmaker.

Our betting tip on the match: Handicap 2 (0) for a coefficient of 2.03 in the 1xbet bookmaker.

Our final betting tip on the match: Correct Score - Mainz 2:3 Hoffenheim for a coefficient of 25.00 in the Betway bookmaker.