St. Pauli vs Bayer Leverkusen: Can Leverkusen break through St. Pauli’s resistance?

St. Pauli vs Bayer Leverkusen Prediction and Odds on 27 September 2025

Leverkusen are in something of a rebuilding phase after losing key players and undergoing managerial changes.  They are still finding consistency. Their performances suggest potential, but too many games have lacked polish in the final third. St. Pauli, though not favorites, have shown grit especially at home, able to frustrate better sides and punish lapses. This match is likely to hinge on whether Leverkusen can impose their tempo and whether St. Pauli can stay organized, avoid mistakes, and maybe steal something on set-pieces or counter-attack.

St. Pauli: Forms and Statistics

At home, St. Pauli have shown signs of stability, averaging ~1.67 goals in recent home games, but also conceding just over 1 goal. They don’t dominate possession often, but are difficult to break down, especially in the midfield and wide areas. Their matches tend to be tighter, fewer gaps, more defensive organization, though sometimes costly mistakes leave them vulnerable to high-quality attacks.

St. Pauli - Lineups

🔖 St. Pauli Predicted Lineup (3-4-1-2)

Vasilj, Wahl, Smith, Dźwigała; Saliakas, Sands, Fujita, Oppie; Sinani; Hountondji.,Lage

⛔️ Unavailable: Ricky-Jade Jones (out), David Nemeth  (out), Jackson Irvine  (doubtful), Danel Sinani (doubtful), Hauke Wahl (doubtful)

👤 Head coach: Alexander Blessin

Bayer Leverkusen: Forms and Statistics

Leverkusen away games show good possession, decent chance creation, and generally good scoring, but also occasional defensive weakness when their press is bypassed. They are efficient when given space, with players capable of making decisive plays. However, transition defense and concentration in off moments are areas of concern.

Bayer Leverkusen - Lineups

🔖 Bayer Leverkusen Predicted Lineup (3-4-1-2)

Flekken; Quansah, Badé,Tapsoba; Vázquez; Andrich, García, Grimaldo; Tillman, Ben Seghir; Schick

⛔️ Unavailable: Martin Terrier (out), Exequiel Palacios (out), Nathan Tella (doubt)

👤 Head coach: Kasper Hjulmand

St. Pauli vs Bayer Leverkusen match prediction 27 September 2025

• In 5 of the last 7 games between St. Pauli and Bayer Leverkusen, bet on over 2.5 goals has played. The bet is offered on the Betway bookmaker website for odds of 1.92 odds;
• In 6 of the last 7 games between St. Pauli and Bayer Leverkusen, bet on BTTS has played. The bet is offered on the Betway bookmaker website for odds of 1.75 odds;

St. Pauli vs Bayer Leverkusen match prediction 27 September 2025

St. Pauli’s form in their last six Bundesliga games includes 2 wins, 2 draws, and 2 losses, averaging ~1.17 goals scored and conceding about 1.33. Their home games see marginally better scoring (≈1.67 goals) but defensive fragility remains a concern. Bayer Leverkusen have obtained two wins, three draws, one defeat; scoring ~2.33 goals per game with ~1.5 conceded. They dominate possession, create a lot of chances, but finishing and defensive lapses sometimes undermine that advantage. 

Leverkusen’s superior squad quality and possession dominance mean they should come out on top.

Below are our predictions

Our match prediction: is BTTS for a coefficient of 1.75 in the Betway bookmaker.

Our betting tip on the match: is over 2.5 goals for a coefficient of 1.92 in the Bet365 bookmaker.

Lastly: is W2 to win for a coefficient of 2.28 in the 1XBet bookmaker.