Lazio vs Milan Prediction: Milan edging towards back-to-back victories over Lazio

Lazio vs Milan: Prediction for the Match on December 04, 2025

Five days after their inaugural league meeting in the Serie A, Lazio and Milan will go head-to-head again at the Stadio Olimpico, this time in the Coppa Italia round of 16. The Rossoneiri secured a narrow 1-0 victory at home against Lazio over the weekend, courtesy of Rafa Leao’s goal, and that victory took them back to the top of the league table. 

Maurizio Sarri’s men will be hoping to put the weekend’s loss behind them as they head into this match-up, and they need all the firepower they can get as they aim for a victory against the league leaders. Can Milan secure back-to-back victories against Lazio? Check the team conditions! Several betting options are available.

Lazio: Form and Statistics

Form in all competitions: LWLWD

Lazio’s loss against Inter at San Siro earlier this month proved to be just the beginning, as they suffered another defeat at the same venue against AC Milan two weeks later.

However, before they clashed with Milan, the Biancocelesti managed to regain some momentum with a solid 2-0 win over Lecce at home. Mattéo Guendouzi broke the deadlock, and Tijjani Noslin sealed the victory with his first Serie A goal in over a year. That result lifted Lazio to eighth in the standings and marked their fifth clean sheet in their last six outings.

Facing Milan over the weekend was a tough test for the Biancocelesti as they failed to convert any of their chances on goal, with Mike Maignan recording 4 solid saves. Rafa Leao scored the only goal of the game for Milan in the 51st minute, and Lazio were unable to respond. Lazio remain 8th placed in the league standings, with 5 wins, 3 draws, and 5 losses from a total of 13 league games played. 

Lazio: Team News and Lineup

Despite dealing with a transfer ban and a growing injury list, veteran coach Maurizio Sarri is squeezing every bit of quality out of the players at his disposal. This week, he will once again link up with the same Milan team that defeated him over the weekend. Sarri will be without Samuel Gigot, Matteo Cancellieri, and Nicolo Rovella

Player to watch out for: Matteo Cancellieri 

23-year-old Matteo Cancellieri is the team's current top scorer in the Serie A with a total of 3 goals in the league. He is currently valued at 5.7M Euros, and his creativity on the ball is very valuable to the team. 

🔖 Lazio starting lineup (4-3-3)

Provedel– Marusic, Romagnoli, Fuentes, Gila – Vecino, Basic, Guendouzi – Zaccagni, Dia, Isaksen

👤 Head Coach: Maurizio Sarri 

Milan: Form and Statistics

Form in all competitions: WWDWD

Before the game against Lazio, the Rossoneri played one of the most important games in the club’s history as far as rivalry is concerned in Italian football. Max Allegri’s side met Inter away from home and, although they spent much of the match on the back foot, they eventually took all three points away. A sharp counterattack in the 54th minute ended with Christian Pulisic scoring in the early hours of the second half to break the deadlock. Milan has not lost a derby game against Inter since the departure of Stefano Pioli. 

Against Lazio over the weekend, Milan once again were not entirely sharp with Cristian Pulisic on the sidelines, and the forward left to Rafael Leao and Cristopher Nkunku. Leao’s goal in the 51st minute was enough to give the Rossoneri the win. Not failing to mention the contribution of an inspired goalkeeper, Mike Maignan, who has won the man-of-the-match award in Milan’s last two games. With their unbeaten run now up to 13 games, Milan have made it clear that they are serious title contenders and they are building their success on a strong defence. Allegri’s side has also kept clean sheets in half of their 7 out of 13 league matches so far, and they’ve lost just once this season. 

Milan News and Lineup

Pulisic, who has scored 16 goals for the Rossoneiri, remains out, and the frontline is now left to Rafael Leao and Cristopher Nkunku. They were the same duo in the front lines against Lazio over the weekend. Zachary Athekame will also not be available for Max Allegri. 

Player to watch out for: Rafa Leao

Leao remains the man to watch out for in this Milan team; his runs from the flank are dangerous, and they can trouble any defense line. Leao is level with Pulisic on league goals this season, as both players have scored five league goals for Milan in the league this season. 

🔖 Milan starting lineup (3-5-2)

Rossi – Danilo, Guillermo Varela, Léo Pereira, Alex Sandro – Jorginho, Erick Pulgar – Luiz Araujo, Giorgian De Arrascaeta, Jorge Carrascal – Bruno Henrique

👤Head Coach: Maximillano Alegri 

Lazio vs Milan: Head-to-Head statistics

In the last ten head-to-head matches, Milan has seven wins, Lazio has two, and there has been one draw. The rivals have met 189 times in total. Milan has 84 wins, Lazio has 41, and there have been 64 draws.

Lazio vs Milan: Betting Tips & Odds

• No losses for Milan in their last 13 games, and the option for Milan to win this game is offered on the BetWay bookmaker website for odds of 2.23;
• Milan has scored first in five of their last six meetings, and the option for Milan to score first is offered on the Bet365 bookmaker website for odds of 1.86;
• Milan has not lost in 13 consecutive matches, and the option for Milan to win or draw this game is offered on the 1xbet bookmaker for odds of 1.36.

Lazio vs Milan match prediction, 04 December 2025

Lazio have struggled in big games this season. Maurizio Sarri’s side have fallen to Inter, Roma, Como, and most recently Milan. In all of those matches, the Biancocelesti failed to score, and also never conceded more than two goals. Their weekend clash with Milan was another test, and it only highlighted how much work they still need to do in the final third. Milan aren’t at their best either, but with a top-class goalkeeper and an experienced midfield, they may have just enough to win this one.

Our match prediction is for Milan to qualify for the next stage for a coefficient of 1.64 in the 1xBet bookmaker.

Our betting tip on the match is for both teams to score, for a coefficient of 1.85 in the Betway bookmaker.

Lastly, A total of under 9.5 corners for 1.79 odds in the Bet365 bookmaker.