Napoli vs Pisa Prediction: expect the victory of the Neapolitans

Napoli vs Pisa: Prediction for the Match on September 22, 2025

Prediction for the Serie A match which will be held on September 22. Who will be stronger? Check the team conditions! Several betting options are available.

Napoli: form and statistics

The Neapolitans played the previous match on Thursday. The team started the main stage of the Champions League with an away match against Manchester City. Already in the 21st minute, Napoli remained in the minority after the removal of Di Lorenzo, and as a result conceded two unanswered goals in the second half - 0:2.

In the championship, Napoli is still without losses, leading the standings along with Juventus. In turn, the Neapolitans beat Sassuolo (2:0), Cagliari (1:0) and Fiorentina (3:1).

Pisa: form and statistics

Pisa won the right to promotion following the results of last season and appointed Alberto Gilardino as head coach in the offseason. The start turned out to be successful – a 1:0 (0:0) victory in the penalty shootout in the Italian Cup over Cesena, but then the team did not start the championship in the best way.

Pisa scored only one point in the opening three rounds. First, Gilardino's team played 1:1 with Atalanta, and then suffered two defeats with the same score 0:1 – from Roma and Udinese.

Napoli vs Pisa: head to head statistics

The rivals met five times. Napoli have three wins, two draws.

Napoli vs Pisa: Betting Tips & Odds

• Pisa's five previous matches turned out to be low-scoring. TU 2.5 is with a coefficient of 2.02.
• Napoli have won three in a row since the start of the championship. The bet is W1 with a coefficient of 1.25.
• Pisa has not scored in 3 of the last 4 matches. The bet is IT2U (0.5) with a coefficient of 1.57.
• In 5 of the 7 previous meetings, Napoli scored at least twice. IT1O (1.5) is with a coefficient of 1.47.

Napoli vs Pisa: Bookmakers' odds for the match

Napoli is a clear favorite of the upcoming match. The bet on the victory of the Neapolitans by the 1xbet bookmaker is offered with a coefficient of 1.25. You can bet on Pisa for a factor of 13.00. For a draw – for 5.90.

In terms of performance, the match is more likely to be a horse race. TO (2.5) is set with a coefficient of 1.80. TU (2.5) is taken as a coefficient of 2.02. You can bet on BTTS – yes for 2.50. BTTS - No bet is estimated at 1.53.

Napoli vs Pisa match prediction 21 September 2025

Pisa, led by Alberto Gilardino, is expected to play defensively. But Antonio Conte's Napoli is not forcing things either. In this regard, we expect a few goals in the upcoming meeting. We are also betting on a laborious, but still a victory for Napoli. The reigning champion started the season well, won three matches in a row in Serie A, and his defeat against Manchester City on Thursday, given the early elimination, should not be overestimated.

Our main prediction: is W1 + Total Under 3.5 for a coefficient of 1.88 in the betway bookmaker.

Our betting tip on the match: is Total Under 2.5 for a coefficient 2.01 in the 1xbet bookmaker.

Our final betting tip on the match: is Correct Score 2:0 for a coefficient 5.50 in the bet365 bookmaker.