Liverpool vs Southampton Prediction: I expect the host to win with multiple goals

Liverpool vs Southampton Prediction and Odds on 23 September 2025

Liverpool will welcome Southampton in the England EFL 1/16 Finals at Anfield Stadium. Liverpool will aim to secure a win and extend their winless streak to seven games, while Southampton, battling a winless streak of three games, will aim to prevent a defeat on the road. Let’s analyse previous results, overall performance, recent forms, and my betting opinion on how to place your bets.

Liverpool: Forms and Statistics

Liverpool are undoubtedly one of the best teams in the world, and they surely aim for a trophy in every competition they participate in. Arne Slot's team started the season with a defeat in the Community Shield, but after that, the team from Anfield secured six straight victories. In the previous game, they won 2-1 at home against Everton. Slot's team didn't dominate as they used to in that match, but they still recorded another triumph. Liverpool had a tough seven days in which they played three matches. In this match, they will aim to secure a win and extend their winning ways.

Liverpool Lineups

The head coach admitted that his team ran out of energy against Everton, so we should expect Slot to rotate the squad and rest the leading players in the EFL Cup against Southampton. Liverpool have some problems with injuries. Stefan Bajcetic, Luke Chambers, and Callum Scanlon are unavailable for the game against Southampton.

🔖 Liverpool predicted lineup (4-2-3-1):

Goalkeeper: Mamardashvili

Defender players: Frimpong, Leoni, Gomez, Robertson

Midfielder players: Nyoni, Endo

Attacking players: Chiesa, Jones, Ngumoha, Isak

⛔️ Unavailable: Callum Scanlon, Luke Chambers, Stefan Bajcetic

👤 Head Coach: Arne Slot

Southampton: Forms and Statistics

Last season, Southampton played in the Premier League, but they ended at the bottom of the standings and returned to the Championship. Southampton started the 2025/26 season as one of the promotion candidates, but started terribly with only six points in six league matches. In the most recent outing, the Saints lost 3-1 on the road against Hull. However, they have recorded three winless streaks in their last four games. In this match, Southampton will aim to secure a win on the road and snap their winless streak.

Southampton Lineups

The visitors primarily played with a three-man defence last season, and Still has shuffled between configurations at the start of his tenure. A back three is likely here, however, given their recent form with a four.

🔖Southampton predicted lineup (3-5-2):

Goalkeeper: McCarthy

Defender players: Edwards, Wood, Stephens

Midfielder players: Roerslev, Fraser, Downes, Jander, Manning

Attacking players: Stewart, Archer

⛔️ Unavailable: Wellington, Edozie

👤 Head Coach: Still W.

Liverpool vs Southampton: Head-to-Head Statistics

Liverpool won four of their last five games, while Southampton failed to secure a win, and both teams tied in one game. However, both teams scored against one another in four games, and more than two goals were recorded in five games.

Liverpool vs Southampton: Betting Tips & Odds

• In four of their last five games between Liverpool and Southampton, they have taken more than 9 corners. This option is provided on the Bet365 bookmaker website for odds of 1.87;
• In four of their last five games between Liverpool and Southampton, they had BTTS. This option is provided on the Betway bookmaker website for odds of 2.00;
• In four of their last five games between Liverpool and Southampton, they had over 3.5 goals. This option is provided on the 1XBet bookmaker website for odds of 1.85;
• In three of their last five games between Liverpool and Southampton, they had more than one goal at halftime. This option is provided on the 1XBet bookmaker website for odds of 1.89;
• In two of their last five games between Liverpool and Southampton, they have had ended in draws at halftime. This option is provided on the Bet365 bookmaker website for odds of 3.18

Liverpool vs Southampton match Prediction 23 September 2025

Liverpool were on fire lately, while Southampton were the underdog. Therefore, I expect the home team to display superior play early on their home soil and secure a win at halftime, while I expect more than one goal to be recorded in this match. However, since I expect the home team to secure a win on their home soil, I expect more than three goals to be recorded in this match, since the home team will aim to score more goals given that the visiting team were weak in their last matchup and conceded more tna two goals.

Below are our predictions for this game.

Our match prediction: Over 1.5 goals at halftime for a coefficient of 1.89 in the 1XBet bookmaker.

Our betting tip on the match: HF W1 for a coefficient of 1.60 in the Betway bookmaker.

Our final betting tip on the match: is Over 3.5 goals for a coefficient of 1.85 in the Bet365 bookmaker.