Los Angeles Rams vs Indianapolis Colts Prediction: Indianapolis Colts seeking to extend winning streak

Los Angeles Rams vs Indianapolis Colts: Prediction for the match on September 28, 2025

Prediction for the National Football League on the 28th of September 2025. SoFi Stadium sets the stage on Sunday as the 2-1 Los Angeles Rams host the undefeated Indianapolis Colts. The Colts roll in at 3-0, but bookies list them as 3.5-point underdogs. The over/under sits at 49.5. It’s a tough road test for Indianapolis, facing a Rams team that rarely makes things easy. Here at Telecomasia, we will preview this game and offer the best betting opportunities.

Los Angeles Rams: Form and Statistics

The Rams have won two games and lost one this week. The Philadelphia Eagles beat them 33–26 in their last game. Matthew Stafford completed 19 of 33 passes for 196 yards. He threw two touchdowns and one interception, giving him a QB rating of 82.4. He got 5.9 yards for every attempt. Kyren Williams ran the ball 20 times for 94 yards, which is an average of 4.7 yards per run. The rushing unit as a whole looked strong, gaining 160 yards on 31 carries at a rate of 5.2 yards per attempt. Puka Nacua was great at throwing the ball. He caught 11 passes for 112 yards, which is more than 10 yards per catch. The Rams' offense gained 356 yards on 65 plays, which is an average of 5.5 yards per play. On defense, they only let the Eagles throw for 202 yards on 65.6% of their passes and only let them run for 86 yards on 27 carries.

Los Angeles Rams: Team News

The Los Angeles Rams are 5th in the NFL in total yards per game this season, with an average of 363.7. They've gotten 35 first downs, but penalties have hurt them. They've lost 130 yards on 15 flags. There haven't been many turnovers; only two interceptions and one fumble have been allowed.

Indianapolis Colts: Form and Statistics

The Indianapolis Colts are doing great so far. They haven't lost yet this year, and they're 3-0 for the first time since 2009, when Peyton Manning was in charge. Daniel Jones is now the quarterback, and Shane Steichen's offense looks good. They won their last game against the Tennessee Titans 41-20. Jones was effective, completing 18 of 25 passes for 228 yards and a touchdown. He had a QB rating of 113.4 and didn't throw any interceptions, so he kept the ball safe. Indianapolis ran 53 plays and gained 365 yards. They ran the ball 28 times and gained 137 yards, or 4.9 yards per attempt. They held Tennessee to 196 passing yards on 60.5% of their attempts and only 86 rushing yards on 23 carries. Their offense has gained 1,256 yards, made 40 first downs, and not turned the ball over at all. They've scored nine touchdowns, three of which were through the air and six on the ground.

Indianapolis Colts: Team News

Jonathan Taylor was the main force behind the attack on the ground. He ran the ball 17 times and gained 102 yards, or six yards per rush. Michael Pittman Jr. was the best receiver in the air, catching six passes for 73 yards, or 12.2 yards per catch.

Los Angeles Rams vs Indianapolis Colts Betting Tips & Odds

• The Colts have scored 34.3 points per game this season, making them one of the most explosive teams in the league. They are running for 153.3 yards per game, which is the third-best in the NFL.
• Indianapolis is 10th in points allowed on defense, with 18.7 per game. They've let up 94 rushing yards per game, which is 4.8 yards per carry, and their pass defense has been even better.
• They are eighth in the league because they only give up 178.3 passing yards per game. They give up an average of 272.3 total yards a week, which is the seventh-best in football. They've given up five passing touchdowns and two rushing touchdowns in three games.
• The Rams have given up 61 points in three games, or 20.3 points per game, which puts them 14th in the league. They've only given up 165.3 yards per game through the air, which is the sixth-best in the league.
• However, they've also given up four touchdowns through the air. They've given up a total of 309 rushing yards on the ground, just one rushing touchdown, and an average of 103 yards per game.
• The defense has made four takeaways—three forced fumbles and one interception—over the course of 184 plays, which puts them 19th in the NFL.

Los Angeles Rams vs Indianapolis Colts Match Prediction 28th September 2025

The Colts are on a roll with a perfect 3-0 record going into Week 4. Now they head west to play the Los Angeles Rams, who are 2-1. Matthew Stafford is in charge of the Rams' offense, which will put Lou Anarumo's pass rush to the test. It hasn't found its spark yet. But that's not the end of the challenge. The Rams' defense is very tough. Braden Fiske, Byron Young, and Jared Verse will put a lot of pressure on Indy's offensive line, which has been strong so far. It seems like this fight is going to be a slugfest. The Colts still have what it takes to beat LA, though it might not be easy. Daniel Jones is the quarterback and Jonathan Taylor is the running back.

Our match prediction is +3.5 Handicap Indianapolis Colts with odds at 1.90 on the 1Xbet bookmaker.

Our betting tip is Over 49.5 Total with odds at 1.95 on the Bet365 bookmaker.

Our final match prediction is Indianapolis Colts to win with odds at 2.60 on the Betway bookmaker.