San Francisco 49ers vs Jacksonville Jaguars Prediction: San Francisco 49ers to get more turnovers in this fixture

San Francisco 49ers vs Jacksonville Jaguars: Prediction for the match on September 28, 2025

Prediction for the National Football League on the 28th of September 2025. Week 4 brings the Jacksonville Jaguars to Levi’s Stadium. They’ll face the San Francisco 49ers on Sunday, September 28, 2025, with kickoff set for 4:05 PM ET. The Jaguars enter at 2–1 under new head coach Liam Coen. Their latest victory came in Week 3 against the Houston Texans. San Francisco stands unbeaten at 2–0. The offense shines brightest with Brock Purdy, but Mac Jones has been steady while Purdy recovers. Here at Telecomasia, we will preview this game and offer the best betting opportunities.

San Francisco 49ers: Form and Statistics

The 49ers beat the New Orleans Saints 26-21, covering as 3-point favorites and going over 40.5. The offense still runs on Christian McCaffrey. He has the most touches in the league (50), but he only averages 3.5 yards per carry, which puts him in 32nd place. He has 124 yards on the ground in two games, but no rushing touchdowns. As a receiver, he's been more explosive, catching 15 of 17 passes for 125 yards and a touchdown, which is an average of 62.5 yards per game. Brock Purdy has thrown for 277 yards, scored two touchdowns, and thrown two interceptions this season. He has thrown 74.3% of his passes, gaining an average of 7.9 yards per attempt and 17 rushing yards. Jauan Jennings has helped out with seven catches for 105 yards and a touchdown, which is 52.5 yards per game.

San Francisco 49ers: Team News

Mac Jones took over for Brock Purdy, who was hurt in the shoulder and toe. He threw for 279 yards and three touchdowns without throwing an interception. He completed 66.7% of his passes at 7.2 yards per attempt. Nick Bosa has been the best player on defense, with 15 tackles, four for loss, and two sacks. Fred Warner leads the team with 19 tackles and two tackles for loss. Dee Winters has made 14 tackles and two tackles for loss, while Marques Sigle has made 11 stops.

Jacksonville Jaguars: Form and Statistics

With new head coach Liam Coen, the Jaguars are 2–1. They won their last game in Week 3 against Houston. They haven't looked great on offense, but they've won two games early on thanks to big plays on both sides of the ball. Trevor Lawrence is still the main focus. He was once called the next NFL superstar, but he's still looking for that big break. There are flashes of brilliance, like the playoff comeback against the Chargers, but consistency keeps slipping away. This year tells the same story. He has thrown for 671 yards, four touchdowns, and four interceptions in three games. His choices have often seemed shaky, which makes him easy to beat by defenses like San Francisco's. The defense has been steady, giving up only 17 points and 292 yards per game. There are 23 tackles by Foyesade Oluokun. Travon Walker has gotten two sacks. Jourdan Lewis has picked off two passes.

Jacksonville Jaguars: Team News

Brock Purdy is the big question for the 49ers. Kyle Shanahan said that he might be able to practice again in Week 4, even though he's missed the last two games because of turf toe. The Niners' defense is still a tough test, with or without him.

San Francisco 49ers vs Jacksonville Jaguars Betting Tips & Odds

• This season, the 49ers remain unbeaten against the spread. As 1.5-point favorites or more, they’ve covered in both games.
• Their totals have split—one over, one under. On the moneyline, they’ve been favored twice and won twice. Oddsmakers now give them a 55.6% chance to win.
• There is balance in Jacksonville. Travis Etienne Jr. is in charge of a rushing attack that gains 141.7 yards per game. He has already scored a touchdown and gained 270 yards. In the passing game, Brenton Strange and Dyami Brown have caught 253 yards and a touchdown, and rookie Brian Thomas Jr. has caught seven passes.

San Francisco 49ers vs Jacksonville Jaguars Match Prediction 28th September 2025

The spread has gone up to 3.5, and that hook makes Jacksonville the team to cover. San Francisco is just too hurt right now. As long as quarterback Brock Purdy passes practice this week, he should be back after missing two games. The 49ers might not have a choice anyway, since Mac Jones has a hurt knee. Nick Bosa is the bigger blow. He tore his ACL and will miss the season, which means San Francisco will lose its defensive anchor. That gives Jacksonville a chance, a team that has done better than expected against pass rushers so far. This will still be the Jaguars' toughest test so far. Even when Purdy isn't at his best, he's a lot tougher than Bryce Young, Jake Browning, or Houston's offense. Jacksonville's defense will find out right away if it can handle the challenge.

Our match prediction is -3.0 Handicap San Francisco 49ers with odds at 1.83 on the 1Xbet bookmaker.

Our betting tip is Over 47.0 Total with odds at 1.90 on the Bet365 bookmaker.

Our final match prediction is San Francisco 49ers to win with odds at 1.60 on the Betway bookmaker.