San Francisco 49ers vs Los Angeles Chargers Prediction: Los Angeles Chargers to Charge at San Francisco 49ers in their final preseason game

The Los Angeles Chargers (2-1) will face the San Francisco 49ers (1-1) in Week 3 of the 2025 NFL Preseason. The Chargers are coming off a narrow 23-22 loss on the road to the Los Angeles Rams, while the 49ers won 22-19 at the Las Vegas Raiders last Saturday. This game will be an interesting way to close out the preseason for both teams. Here at Telecomasia, we will preview this game and provide the best betting opportunities.

San Francisco 49ers: Form and Statistics

Malik Jones was efficient in limited snaps, completing 17 of 23 passes for 209 yards, though he has yet to throw a touchdown. Wideout Robbie Chosen has been the most consistent receiving threat, with six catches for 93 yards. The 49ers will aim to control the tempo on the ground, where Corey Kiner has led with 68 rushing yards, though he is currently questionable.

San Francisco 49ers: Team News

The 49ers’ defense showed some improvement last week, but still allowed 19 points to a Raiders offense that struggled in Week 1. Pass defense is the biggest concern, especially with injuries to Bradlee Anae and CJ West. The secondary has only forced two turnovers in the first two games. With several defensive starters sidelined, San Francisco may need its offense to carry the load again in this game.

Los Angeles Chargers: Form and Statistics

The Los Angeles Chargers are looking to make progress in coach Jim Harbaugh’s second year, despite dealing with injuries. They started the 2025 preseason with a big 34-7 win over the Detroit Lions in the Hall of Fame Game, followed by a 27-13 victory against the Saints. Last week, they lost a close game to the Los Angeles Rams on a last-second touchdown. Trey Lance has been leading the offense, completing 27 of 49 passes for 296 yards and two touchdowns, while also rushing 14 times for 81 yards and a score. He will start in Saturday’s preseason finale. Backup quarterback Taylor Heinicke has also seen action, going 6-of-11 for 56 yards, while Lance went 7-of-15 for 121 yards in earlier games.

Los Angeles Chargers: Team News

Rookie wide receiver KeAndre Lambert-Smith has impressed, recording over 100 receiving yards on just four catches. The offense will rely on the backup QB spot, but Lance has shown he can manage both the passing and running game. The defense has struggled, allowing 23 points and 458 total yards (324 passing, 134 rushing) against the Rams. They also gave the Rams possession for nearly 36 minutes, allowing 6.0 yards per play. Improving the defense will be key for the Chargers as they finish the preseason.

San Francisco 49ers vs Los Angeles Chargers Betting Tips & Odds

• Mac Jones threw for 135 yards and an interception, completing 13 of 16 passes. Carter Bradley threw for 96 yards on 8 of 13 passing. Ke’Shawn Vaughn rushed for a team-high 24 yards, while Corey Kiner added 23 yards on the ground. Robbie Chosen led the team with 5 receptions for 92 yards. Demarcus Robinson had 3 catches for 44 yards, and Ricky Pearsall also had 3 grabs for 42 yards. The bookies has Over 35.5 runs available on Bet365 Bookmaker at the odds of 1.909.
• On defense, Nick Martin recorded a team-high 6 total tackles, including 5 solo tackles and a sack. Chazz Surratt also had 6 total tackles with 5 solo tackles. Trevis Gipson, Demone Harris, and Chase Lucas each recorded a sack, and Lucas and Jaylen Mahoney both had an interception. The bookies have Over 16.5 Total 1 at 1.833 odds for 1xbet bookmaker.

San Francisco 49ers vs Los Angeles Chargers Match Prediction 24th August 2025

The Los Angeles Chargers have shown more balance and explosiveness on offense, led by Trey Lance. Despite injuries, the Chargers have received better production from their backups, especially compared to the San Francisco 49ers, who are yet to find rhythm on either side of the ball. The Chargers have played one more preseason game and have given up fewer total points than the 49ers (49 to 43). Trey Lance has emerged as a solid backup quarterback, while Mac Jones is among the names on the injury report for the 49ers. KeAndre Lambert-Smith has been impressive in limited action, while San Francisco is still searching for wide receivers to step up. With their better overall performance, the Los Angeles Chargers are the safer bet to win on the road.

Our match prediction is -1.5 Handicap Los Angeles Chargers with odds at 1.893 on the 1Xbet bookmaker.

Our betting tip is Over 35.5 runs with odds at 1.909 on the Bet365 bookmaker.

Our final match prediction is Los Angeles Chargers to win with odds at 1.741 on the Betway bookmaker.