San Francisco 49ers vs Tennessee Titans Prediction: Can the 49ers cover as big favorites at home?

San Francisco 49ers vs Tennessee Titans: Prediction for the match on December 14, 2025

The San Francisco 49ers will play the Tennessee Titans in Week 15 at Levi's Stadium on Monday. The 49ers (9-4) are heavy favorites, with a spread of -12.5 over the Titans (2-11). San Francisco has won three straight games. The over/under for the game is set at 44.5 points. Here at Telecom Asia, we break down the matchup and share our top betting picks for this exciting game.

San Francisco 49ers: Form and Statistics

Christian McCaffrey averages 3.6 yards per carry and 65.3 yards per game. He has 849 total rushing yards and eight rushing touchdowns. In the passing game, McCaffrey has 85 catches on 107 targets for 806 yards and five touchdowns. Mac Jones has thrown for 2,151 yards, 13 touchdowns, and six interceptions. He averages 215.1 yards per game, 7.4 yards per attempt, and completes 69.6% of his passes. Brock Purdy has 1,147 passing yards, nine touchdowns, and seven interceptions. He completes 66.3% of his passes, averaging 229.4 yards per game and 7.2 yards per attempt. He has 43 rushing yards and one rushing touchdown. Jauan Jennings averages 3.7 receptions and 41.6 yards per game. He has 458 receiving yards, 41 catches, 69 targets, and five touchdown receptions.

San Francisco 49ers: Team News

Dee Winters leads the 49ers with 84 tackles and 6.0 TFL in 2025. Upton Stout follows with 64 tackles, 4.0 TFL, and one sack. Bryce Huff leads the team in sacks with 4.0, adding 6.0 TFL and 23 tackles. Ji'Ayir Brown has 44 tackles, 1.0 TFL, and two interceptions.

Tennessee Titans: Form and Statistics

Cameron Ward has thrown for 2,468 yards this year, with nine touchdowns and seven interceptions. He completes 59.1% of his passes, averaging 189.8 yards per game and 5.6 yards per attempt. Ward has added 127 rushing yards (third on the Titans) and one rushing touchdown. He averages 9.8 yards per game and 4.2 per carry. Tony Pollard leads the Titans with 743 rushing yards and four touchdowns. He averages 57.2 yards per game and 4.2 per carry (23rd in the NFL). Pollard also has 27 catches for 171 yards. He’s been targeted 34 times, averaging 13.2 yards per game. Chimere Dike has 284 receiving yards and three touchdowns on 34 receptions, with 55 targets this season.

Tennessee Titans: Team News

Elic Ayomanor has 30 catches for 353 yards after 67 targets. On defense, Cedric Gray has 124 tackles, 6.0 TFL, one sack, and four passes defended. Jeffery Simmons leads the Titans with 8.0 sacks, 12.0 TFL, and 48 tackles. Cody Barton has 1.0 sack, 4.0 TFL, 67 tackles, and three interceptions. Amani Hooker has 69 tackles, 3.0 TFL, one sack, and seven passes defended.

San Francisco 49ers vs Tennessee Titans Betting Tips & Odds

• San Francisco and Tennessee are tied 1-1 in their last two matchups. In those games, Tennessee scored 43 points against San Francisco while allowing 42.
• San Francisco has played 13 games this season, winning eight against the spread. The 49ers have gone over the point total 53.8% of the time (7 out of 13 games).
• San Francisco has an 8-1 record as a moneyline favorite, winning 88.9% of those games. They have a 90.0% chance to win based on the moneyline.
• Tennessee is 6-7 against the spread this season. The Titans have not covered the spread this season as underdogs by 12.5 points or more.
• Eight of Tennessee’s games have gone over the point total. The Titans have won 15.4% of their games as underdogs this season. The moneyline gives them a 14.3% chance to win this game.

San Francisco 49ers vs Tennessee Titans Match Prediction 14th November 2025

Christian McCaffrey continues to dominate for San Francisco. He leads the team in both rushing yards (849) and receiving yards (806), with a wide gap over the rest. McCaffrey also has 13 touchdowns this season, eight rushing and five receiving. This is a big spread, but the 49ers have shown they can cover it. They beat the Browns by 18, Panthers by 11, Cardinals by 19, and Giants by 10 in their last four wins. The Titans may feel good after their win in Cleveland, but that was against a weak team. The 49ers are fighting for playoff position and a first-round bye. They won’t take it easy on the Titans at home.

Our match prediction is -12.5 Handicap San Francisco 49ers with odds at 1.90 on the 1Xbet bookmaker.

Our betting tip is Under 44.5 Total with odds at 1.90 on the Bet365 bookmaker.

Our final match prediction is the San Francisco 49ers to win with odds at 1.60 on the Betway bookmaker.