Seattle Seahawks vs Indianapolis Colts Prediction: Seattle favored by double digits

Seattle Seahawks vs Indianapolis Colts: Prediction for the match on December 14, 2025

The NFL’s quarterback drama now shifts to the Pacific Northwest. Daniel Jones' season-ending injury has turned what should have been a competitive Week 15 game into a potential blowout. Seattle’s Lumen Field will host a matchup between two teams heading in opposite directions. The Seahawks are on a three-game win streak, while the Colts are fighting to stay in the playoff race with rookie Riley Leonard making his first start. Seattle is favored by -13.5. The over/under is set at 42.5 points. Here at Telecom Asia, we break down the matchup and share our top betting picks for this exciting game.

Seattle Seahawks: Form and Statistics

Jaxon Smith-Njigba leads the NFL with 1,428 receiving yards, from 89 catches on 121 targets. He averages 6.8 catches and 109.8 yards per game, with nine touchdowns, ranking second in the league. Sam Darnold has 3,162 passing yards, 22 touchdowns, and 11 interceptions. He completes 68.1% of his throws, averaging 243.2 yards per game and 8.9 per attempt. Kenneth Walker III has 762 rushing yards in 13 games, averaging 58.6 yards per game and scoring four touchdowns. He also has 21 receptions for 174 yards but no receiving touchdowns. Zach Charbonnet has 483 rushing yards, averaging 40.3 yards per game, and eight touchdowns. Mike Macdonald’s Seahawks have won seven of their last eight games. Their defense has been dominant, allowing just nine points in the last two games. They shut out Minnesota and held Atlanta to a field goal, outscoring opponents 63-9 in that span. With steady play from Darnold and Smith-Njigba’s record-breaking season, the Seahawks are strong NFC contenders.

Seattle Seahawks: Team News

Seahawks Injury Report: Jared Ivey – out, Elijah Arroyo – questionable, Brandon Pii – questionable

Indianapolis Colts: Form and Statistics

Jonathan Taylor has rushed for 1,356 yards and 16 touchdowns this season, averaging 104.3 yards per game and 5.5 per carry. He also has 35 receptions for 304 yards and two receiving touchdowns. Michael Pittman Jr. has 69 catches for 699 yards and seven touchdowns, ranking seventh in the NFL. He averages 5.3 receptions per game and has been targeted 94 times. Tyler Warren has 60 catches for 699 yards and four touchdowns, averaging 4.6 receptions per game. Alec Pierce has caught 38 passes for 769 yards on 67 targets. The Colts arrive in Seattle after losing three straight games and four of their last five. Their latest loss was a 36-19 defeat to Jacksonville, which saw Jones tear his Achilles. Rookie Riley Leonard is now the starting quarterback after a rough 145-yard, one-interception performance in relief. The Colts’ offense faces a tough task against one of the NFL’s best defenses, with veteran Philip Rivers added to the practice squad for emergency depth.

Indianapolis Colts: Team News

Colts Injury Report: Daniel Jones – out, Alec Pierce – questionable, Anthony Gould – questionable, Braden Smith – questionable, Chris Lammons – questionable, T Tuimoloau – questionable

Seattle Seahawks vs Indianapolis Colts Betting Tips & Odds

• Seattle has beaten Indianapolis twice in their last two matchups. Over those games, Seattle scored 74 points, while Indianapolis posted 34.
• Seattle has played 13 games this season, winning 10 against the spread. The Seahawks have hit the over in 8 of 13 games (61.5%).
• When favored on the moneyline, Seattle has won 90% of the time (9-1). Their implied win probability for this game is 92.3%.
• Indianapolis is 7-6 against the spread this season. The Colts have hit the over in 7 of 13 games. They have covered the spread seven times over 13 games with a set total.
• The Colts are 3-4 against the spread on the road, while Seattle is 4-2 at home. This season, the Colts have won two of four games as underdogs. Their implied win probability on the moneyline is 11.8%.

Seattle Seahawks vs Indianapolis Colts Match Prediction 14th November 2025

The Seahawks are the clear choice in this game. Their defense can slow down Jonathan Taylor, and the Colts will likely have to abandon the run once Seattle takes the lead. Seattle has outscored opponents 63-9 in the past two weeks, following a close win over Tennessee and a loss to the Rams. The Seahawks have covered as favorites all season, and that should continue against a Colts team in freefall.

Our match prediction is +13.5 Handicap Indianapolis Colts with odds at 2.00 on the 1Xbet bookmaker.

Our betting tip is Over 42.5 Total with odds at 1.90 on the Bet365 bookmaker.

Our final match prediction is the Seattle Seahawk 1st team drive outcome with odds at 1.60 on the Betway bookmaker.