New York Giants vs Kansas City Chiefs Prediction: can New York’s passing game keep up?

New York Giants vs Kansas City Chiefs: Prediction for the match on September 22, 2025

Prediction for the National Football League on the 22nd of September 2025. The New York Giants face the Kansas City Chiefs in MetLife Stadium, East Rutherford, NJ on Sunday, as both teams prepare for the third fixture of the season. The New York Jets have recorded three wins and two losses in the last five matches. Here at Telecomasia, we will preview this game and offer the best betting opportunities.

New York Giants: Form and Statistics

The Giants have been a mixed bag. They dropped 37 points on Dallas, yet their offense still feels uneven. The run game has struggled, averaging just 79 yards per contest, and Russell Wilson has already been sacked five times in two weeks. Wilson remains the spark. He ranks second in the NFL with 618 passing yards, tossing three touchdowns against one interception. He’s completing 60.3% of his throws and averaging 309 yards per game at 7.9 yards per attempt. On the ground, he leads the team with 67 rushing yards. Malik Nabers has been the breakout star. He’s pulled in 14 catches for 238 yards, leading the league in receiving yards. He averages over 100 yards per game, with two touchdowns and 25 targets already. Wan’Dale Robinson has also stepped up. Through two games, he’s matched Nabers with 14 catches, adding 197 yards and a touchdown. Cam Skattebo is trying to keep the run game alive. He has 42 rushing yards and one score, averaging just over 21 yards per game. As a receiver, he’s added 26 yards on four catches but is still searching for his first touchdown through the air. The defense hasn’t helped much. New York has given up 40 points in one game and 21 in the next. With injuries piling up — Jalin Hyatt, Jon Runyan, and several defenders on the list — the Giants need balance fast. Against Kansas City, it will take more than Wilson’s arm and Nabers’ speed to finish drives.

New York Giants: Team News

These New York Giants Players will not play in this fixture. They are Dimukeje V. (Muscle Injury), Ezeudu J. (Injury), Flannigan-Fowles D. (Calf Injury), Ford-Wheaton B. (Achilles Tendon Injury), Gray E. (Injury), Johnson Jr. A. (Injury), McFadden M. (Foot Injury), Moore T. (Leg Injury), and Payton R. (Injury).

Kansas City Chiefs: Form and Statistics

Kansas City is having a rare bad time. The Chiefs have lost five games in a row, starting with the preseason. They lost to the Eagles, the Chargers, and the Bears. Patrick Mahomes is trying to get things back on track. He has thrown for 445 yards, two touchdowns, and one interception in two games, completing 58.8% of his passes. He has the most rushing yards and touchdowns on the team, with 123 yards and two touchdowns. He averages more than 60 yards per game. In every game, he has thrown and run for a touchdown. Hollywood Brown has been his main target. He has 15 catches for 129 yards, six of which were for first downs and one was for 49 yards. He caught 10 passes for 99 yards in the first game against the Chargers. But he's still looking for his first touchdown.

Kansas City Chiefs: Team News

Travis Kelce has caught six passes for 108 yards and a touchdown, and Tyquan Thornton has caught four passes for 100 yards and a touchdown. The run game, on the other hand, has been shaky, with Kareem Hunt only getting 3.6 yards per carry. Injuries to tight ends and receivers have only made the offense less stable. Effort hasn't been the problem on defense. Drue Tranquill has been the unit's rock, making 11 tackles, two tackles for loss, and two sacks. With 18 tackles, Chamarri Conner is the team's leader. Jaylen Watson is next with 15, and Nick Bolton is third with 14. The line isn't very deep, though, because both Felix Anudike-Uzomah and Mike Danna are hurt.

New York Giants vs Kansas City Chiefs Betting Tips & Odds

• Kansas City enters this matchup still searching for its first cover of the season. Their games have gone over once in two tries.
• As moneyline favorites, they’ve played one game and lost it. Even so, the odds give them a strong 75.3% chance to win here.
• New York has battled Kansas City evenly in their last two meetings, splitting 1-1 and matching them with 29 total points apiece. This year, the Giants are 1-1 against the spread, but they’ve struggled as heavy underdogs.
• They’re winless ATS when catching six or more points, and they’ve lost both games as underdogs outright. Only one of their games has hit the over. The moneyline gives them just a 29% shot to pull off the upset.

New York Giants vs Kansas City Chiefs Match Prediction 22nd September 2025

Chris Jones is hunting his first sack of the year, and the Giants’ shaky line may give him the chance. Pressure up front will matter. If the Chiefs’ defense rattles Russell Wilson, it could limit his deep strikes to Malik Nabers. With veterans banged up, Kansas City’s rookies on defense may also get their moment. On the betting side, the market still leans toward Kansas City’s reputation. Even at 0–2, the Chiefs enter as six-point road favorites, a nod to Mahomes’ presence. The total sits at 45.5, pointing to a mid-scoring clash shaped by Kansas City’s uneven offense and New York’s leaky defense. Sharps may eye the Giants’ home trends, while the public usually sides with the Chiefs’ brand.

Our match prediction is -6.0 Handicap Kansas City Chiefs with odds at 1.90 on the 1Xbet bookmaker.

Our betting tip is Over 44.5 Total with odds at 1.86 on the Bet365 bookmaker.

Our final match prediction is a moneyline of Kansas City Chiefs (1st Quarter Chief) with odds at 1.64 on the Betway bookmaker.